Talk:Ibogaine
The dosage recommendation is too much by far.
From TiHKAL:
"As was pointed out in a pharmacological review (see Popik et al.), as the hallucinogenic dose appears to be several times higher than the stimulant dose, the user must endure intense and unpleasant central stimulation in order to experience the hallucinogenic effects."
and
"There is no question but that ibogaine is a rough trip, physically as well as mentally. Here is one report that shows the body aspects of its use."
The stimulating effects start at doeses at low as 1-2 mg/Kg.
Responses are quite individual. There are fatal cases reported already at 5mg/Kg.
Usually, the hallucinogenic dose is around 10 mg/Kg but this is by no means a medium dosage.
Usually, the sense of balance is strongly disturbed, the heart may beat irregularly (arhythmias, in the sense of a large heart rate variability). Anything besides lying down in bed during the first hours of the experience is probably a bad idea.
What should be noted definitely is the dosing for iboga tabernanthe root bark, which is the most readily available source of ibogaine. Good material contains up to 10% of iboga alkaloids, i.e. 1g of t. iboga root bark contains 50-100mg iboga alkaloids.
I concur, the dosage information here is pretty bad
I agree the dosage information here is actually pretty dangerous. 15-22mg/kg is a typical FLOOD dose, this is effectively the maximum that really should ever be consumed, and should be considered a VERY STRONG dose. Even the Bwiti don't take such high cumulative dosages, those dosages are specifically for opioid detox. A user taking this dose would be completely immobilized and at some non-negligible risk of heart complications.
Threshold effects appear between 50mg, published dosage escalation taper strategies have used dosages ranging from 100mg-600mg. it can be quite managable and rather enjoyable and functional in this range. I can cite clinical trials and case studies exploring these dosage ranges for a better dose response curve here. Not to mention a lot of more recently, lower flood-dose protocols, anywhere from 8-15mg/kg, have been used in more recent research.
It should also be noted that doses in excess of 12mg/kg have been reported to have higher instances of cardiac abnormalities, and should be considered higher risk.
I say we set Threshold to 50mg, light: 300mg, common: 8-12mg/kg, strong 12-15mg/kg, and heavy:15-22mg/kg
I am considering just editing this myself but i dont wanna fuck it up. but really it's not good harm reduction the way it is.
https://akjournals.com/view/journals/2054/1/1/article-p29.xml
https://www.iceers.org/ibogaine-research-methadone-tolerance/