Caffeine/Summary

Main article: Caffeine

Psychoactive class: Stimulants

Chemical class: Xanthines

Oral

Thresh Common Heavy

10 - 20 - 50 - 150 - 500 mg

Light Strong
- Total: 2 - 5 hours
- Onset: 5 - 10 minutes
- Come up: 10 - 60 minutes
- Peak: 1 - 2 hours
- Offset: 6 - 10 hours
- Afterglow: 2 - 4 hours

Insufflated

Thresh Common Heavy

2.5 - 10 - 25 - 40 - 80 mg

Light Strong
- Total: 1 - 2.5 hours
- Onset: 0.5 - 2 minutes
- Come up: 0.5 - 2 minutes
- Peak: 0.5 - 1 hours
- Offset: 6 - 10 hours
- Afterglow: 6 - 24 hours

Smoked

Thresh Common Heavy

25 - 25 - 75 - 125 - 175 mg

Light Strong
- Total: 45 - 70 minutes
- Onset: 2 - 5 minutes
- Peak: 10 - 20 minutes
- Offset: 30 - 45 minutes
- Afterglow: 2 - 4 hours

Harm potential

- Develop with regular consumption, leading to cravings and withdrawal effects upon sudden cessation, but has low abuse potential
- The LD50 of caffeine in humans is dependent on individual sensitivity, but is estimated to be about 150 to 200 milligrams per kilogram of body mass or roughly 80 to 100 cups of coffee for an average adult

Tolerance

- Full tolerance is reached develops with prolonged and repeated use
- Decreases to half after 3 - 7 days
- Returns to baseline after 1 - 2 weeks
- Cross-tolerance with antagonists adenosine receptors

See also

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