Codeine/Summary

Oral

• Thresh				Common				Heavy
  30	-	50	-	100	-	150	-	200	mg
  		Light				Strong

• • Total: 3 - 6 hours
  • Onset: 30 - 45 minutes
  • Come up: 1 - 2 hours
  • Peak: 3 - 5 hours
  • Offset: 2 - 4 hours

Harm potential

• • Moderately addictive with a high potential for abuse
  • Low toxicity, potentially lethal when mixed with depressants like alcohol or benzodiazepines

Tolerance

• • Full tolerance is reached develops with prolonged and repeated use
  • Decreases to half after 3 - 7 days
  • Returns to baseline after 1 - 2 weeks
  • Cross-tolerance with all other opioids

Physical effects

• • Appetite suppression
  • Cough suppression
  • Pain relief
  • Respiratory depression
  • Sedation
• • Constipation
  • Difficulty urinating
  • Itchiness
  • Nausea
  • Respiratory depression

Visual effects

Cognitive effects

• • Cognitive euphoria
  • Compulsive redosing
• • Anxiety suppression
  • Sleepiness
  • Thought deceleration