Dosage

The user should avoid dosages that they are uncomfortable or unfamiliar with. An inexperienced user should always start at a lower dosage with the goal of working their way up to a normal or common dose. This allows the user to verify that their bodies are compatible with the substance and do not exhibit any allergies or unusual sensitivity.

After the initial test, the user may decide to increase the dosage. It is advised to increase the amount in controlled increments, usually adding 1/3 to 1/2 the previous dose. However, some substances are notable tricky to work with. For example, 2C-P has slow onset, steep dose-response curve, and long half-life! So please be patient with new substances! The dose should never be doubled or tripled as this vastly increases the likelihood of either a bad trip or side effects such as anxiety, panic attacks, and psychosis.

This minimizes the risk of an accidental negative experience enormously; it is important to remember that everybody reacts differently to every substance depending on factors such as their own personal tolerance, brain chemistry, body weight, metabolism, stomach contents, and personal sensitivity. Another factor to consider is substance purity which can differ between batches of product.

For information on the appropriate dosage for any substance, research should be done using a combination of PsychonautWiki, Erowid, Tripsit, Wikipedia, Bluelight, and Google. If contradictory information about dosage is found, one should always start from the lowest in order minimize the risk.

Allergy testing

Some people, especially those with health issues or over-reactive immune systems, may have adverse or allergic reactions to substances such as uncomfortable physical or cognitive effects, or over-sensitivity.^[1] The best way to prevent this is to perform an allergy test with every new batch of a substance the user receives (even if coming from a reliable source, as sometimes much more potent and dangerous compounds can become unintentionally mixed up with the product being advertised).

To properly perform an allergy test, one can simply dose a minuscule amount of the substance (1/6 of a regular dose) and then wait several hours to a few days.

When performing an allergy test, one should note any unusual side effects including rashes, hives, breathing discomfort, an uncomfortably fast heartbeat, or a burning sensation on one's skin.^[1] Depending on the severity of symptoms, medical services may be needed.

There are various ways in which users measure their dosages of psychoactive substances. The most accurate and safe method to measure one's drugs is to use a combination of a milligram scale and the volumetric liquid dosing method. This is a vastly far safer route than "eyeballing" one's dosages by approximating the weight of what they are ingesting simply by looking at it and making a rough (but inaccurate) guess.

Avoid using personal cards (e.g. ID or debit card) to line up substances, including halving doses below 10 mg that have been weighed with a milligram scale; If you're going out and get caught, here is a risk that the police will swab your card with color-tests reagents to indicate if your card is contaminated with illegal substances.

Milligram scales

Milligram scales under $1000 cannot accurately weigh out doses below at least 50mg and are highly inaccurate under 10-15mg, for more accurate readability add the included calibration weight to the scale without taring before you add a 10+ mg dose. For more potent drugs, users are strongly advised to use volumetric liquid dosing.

When buying chemicals in powdered form, it is strongly recommended that one invest in a reliable and accurate digital milligram scale to ensure that they are ingesting a safe and recommended dosage. A simple $20-30 investment in such equipment can be the difference between a safe and enjoyable experience, and a negative and dangerous one.

To achieve the most accurate measurement, the scale should only be used on a completely flat surface away from vibrations, wind, and drafts. Low batteries can also affect the scale's accuracy, so one should occasionally replace them.^[2]

There are a huge variety of different scales available online through various sites. To choose a quality scale, users should read the reviews before buying and come to their own personal decision. Users should ideally choose a scale that has a 0.001 g readability. When using a scale that has 0.005 gram (5 mg) accuracy, the weight will be off by 5 mg in either direction, meaning that if one measures 20mg of a substance, the results will be between 15-25 mg.

Terminology^[3]

• Accuracy: Closeness of the agreement between the determined result and the true value.
• Cornerload: Inaccuracy of the balance factor for objects that are not placed centrally on the balance.
• Linearity: The capability of the balance to follow the linear relation between the load and the displayed value.
• Precision: Extent of mutual agreement between of several measured values, independent of the true value.
• Readability: The smallest difference between two measured values that can be read on the display.
• Repeatability: The ability of a balance to provide the same result for repeated weighing of the same load under the same measurement conditions.

For general purpose usage, the following products can be used. Some of these scales below are recommended by TripSit.^[4] The scales are sorted by maximum quantity because a 0.001 x 20 g scale will provide better accuracy than a 0.001 x 100 g scale.

• Milligram scales
  • 0.001 x 20 g
    • American Weigh Scales Gemini-20: US, UK
  • 0.01 x 100 g with wide weighing plate (useful to weigh whole plants parts and mushrooms)
    • Weigh Gram: US, UK

Weighing technique

Most milligram scales are more accurate in higher ranges (5 - 15 grams) than the lower ranges. Therefore, it is better to weigh one's drug while the included calibration weight is on the scale. The following steps outline the weighing method for the most accurate measurement:

1. Place scale on completely flat surface away from wind and vibrations
2. Make sure that the correct weighing unit is chosen, as it might have been changed accidentally.
3. Calibrate scale
4. Add the calibration weight that comes with the scale onto the scale without tarring
5. Add empty gel capsule and mark down weight without tarring
6. Add the powder into the gel capsule
7. Mark down weight of filled capsule
8. Subtract the weight in step 4 from the final weight in step 6
9. Use volumetric liquid dosing afterward, especially for very potent drugs (under 10 mg)

Volumetric liquid dosing

Volumetric liquid dosing should preferably be used for potent drugs because most standard milligram scales cannot accurately weigh out doses below 10-15mg.^[5]

Volumetric liquid dosing is the process of dissolving a known quantity of a compound in a liquid medium in order to make it easier to measure and accurately dose. In the interest of harm reduction, it is essential to prepare certain compounds which are too potent to measure with traditional weighing scales within a liquid solution. Please see the above article for more information about this form of measurement.

The range and intensity of the effects of a substance depends on upon a number of factors. These include route of administration, dosage, set and setting, and personal and environmental factors.

Effective doses can be divided into five categories: threshold, light, common, strong, and heavy.

• Responsible use
• Shulgin Rating Scale
• Duration
• Routes of administration

• The Importance of Measured Doses (Erowid)