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Methadone/Summary
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Main article: Methadone
Psychoactive class:
Opioids
Chemical class:
Diphenylpropylamine
Oral
Thresh
Common
Heavy
1
-
3
-
5
-
15
-
30
mg
Light
Strong
Total
: 10 - 19 hours
Onset
: 20 - 90 minutes
Come up
: 2 - 4 hours
Peak
: 4 - 6 hours
Offset
: 4 - 6 hours
Afterglow
: 1 - 24 hours
Harm potential
Extremely addictive with a high potential for abuse
Moderate toxicity, potentially
lethal
when mixed with
depressants
like
alcohol
or
benzodiazepines
Tolerance
Full tolerance is reached develops with prolonged and repeated use
Decreases to half after 3 - 7 days
Returns to baseline after 1 - 2 weeks
Cross-tolerance with all other
opioids
Physical effects
Appetite suppression
Cough suppression
Pain relief
Respiratory depression
Sedation
Abnormal heartbeat
Constipation
Difficulty urinating
Itchiness
Nausea
Respiratory depression
Visual effects
Internal hallucination
Cognitive effects
Cognitive euphoria
Compulsive redosing
Anxiety suppression
See also
Responsible use
Summary index
Subjective effect index
Psychoactive substance index