Tetrahydrocannabiphorol

Summary sheet: Tetrahydrocannabiphorol

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Tetrahydrocannabiphorol (THCP) is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist with psychoactive effects. Initial in-vitro binding assay studies suggest that THCP may be up to 30 times more potent than delta-9-THC,^[1]^[2] potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.

History and culture

Pharmacology

Binding affinities of THCP for CB1 and CB2 receptors, with D8/D9 THC comparisons.^[1]

Subjective effects

The subjective effects have not been fully understood, but it is known that THCP boasts a longer alkyl side chain than THC,^[3] which might contribute to it's ability to better connect with human cannabinoid receptors CB1 and CB2.^[4]

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index.

Toxicity and harm potential

Tolerance and addiction potential

Dangerous interactions

Legal status

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United States: THCP is not currently classified under any drug schedule in the United States, but it is federally legal.

External links

References

↑ ^1.0 ^1.1 Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G (December 2019). "A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ⁹-tetrahydrocannabinol: Δ⁹-Tetrahydrocannabiphorol". Scientific Reports. 9 (1): 20335. Bibcode:2019NatSR...920335C. doi:10.1038/s41598-019-56785-1. PMC 6937300  . PMID 31889124.
↑ https://www.livescience.com/new-potent-cannabinoid.html
↑ Unraveling the Differences Between THCP and THC, FloraFlex
↑ Why Does Alkyl Chain Length Matter, Cayman Chemicals

[Citti_et_al_2019-1] 1.0 ^1.1 Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G (December 2019). "A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ⁹-tetrahydrocannabinol: Δ⁹-Tetrahydrocannabiphorol". Scientific Reports. 9 (1): 20335. Bibcode:2019NatSR...920335C. doi:10.1038/s41598-019-56785-1. PMC 6937300  . PMID 31889124.

[2] ttps://www.livescience.com/new-potent-cannabinoid.html

[3] Unraveling the Differences Between THCP and THC, FloraFlex

[4] Why Does Alkyl Chain Length Matter, Cayman Chemicals

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