Talk:Simple LSA extraction

I have been searching for any other source for the sulfur vs CYANOGENIC GLYCOSIDES theory and find no unique cases. Sulfur is a factor in the detoxification of cyanide in humans but the process involves the live and an enzyme. PoisonSense > Ordinarily cyanide is detoxified in the liver by the enzyme rhodanase in the presence of sulphur containing amino acids or thiosulphate (a sulfur donor), to produce a less toxic thiocyanate which is largely excreted through the

I have found some forum posts that indicate that taking MSM and a clove of garlic prior to ingesting cyanoglycosides in woodrose seeds has helped some but the test were not blind and some people do not always experience much nausea from the seeds. nothing to urgent but (lsa containing seeds) [Archive - Bluelight] > WIM has taken a few joint supplement pills containing several sulfate compounds and followed an hour later by a nugget of fresh garlic. 2 hours later a water extract of 10-15 hbwr was ingested. Nausea was neglegible if not totally absent... for the first time ever compared to SWIM previous journeys with hbwr and MG's. The experiments employed were carried out the same way: 1. using simple water extract and filtering (no sulfur) 2. using simple water extract in addition to sulfur supps and garlic ingested separately before the liquid extract. Several occassions, several weeks in between, for both experiments using the same seeds from the same bags for accurate comparisons.

update: I found another use of garlic added to the water durring extraction here Cold water extraction of LSA from morning glory seeds - Garlic! MSM! : Drugs I should have searched Morning Glory as well as woodrose?

Hawaiian Baby Woodrose-induced nausea doesn't seem to fit with alleged cyanide poisoning.

If it was the case, that cyanogenic glycosides were responsible, then simply grinding the seeds and letting them sit should take care of it. Plants store these glycosides as defense against predation, and contain enzymes to produce cyanide when chewed. But once produced, the cyanide escapes as a gas. A lot of crops that humans eat contain these glycosides, and for cassava, simple boiling in water is known to remove >96% of cyanogens (Ngudi DD, et al. (2003) Food and Chemical Toxicology; 41: 1193-1197.)

I should point out that many crops, like broccoli, also contain glucosinolates, which are considered to be a major source of health benefits (Das, Amrish et al. CURRENT SCIENCE, VOL. 79, NO. 12, 25 DECEMBER 2000 p1665), despite the production of isothiocyanites in the same manner as the glycosides.

Garlic does seem to have an effect on the lethality of cyanide (Comp Clin Pathol (2006) 15:211–213) in rats, due to some sulfur compound (garlic is all sulfur compounds it seems). But it seems unnecessary here, and would add an off-note to your cocktail.

So while the treatment of the seeds still makes sense IF cyanide is the source, even if it's not the best treatment, the question remains: does this protocol reduce the nausea? The sickness I experienced fits more with the usual alkaloid upset that comes with eating random plant parts. So far there is nothing to suggest it works, that I've seen.

This protocol may work anyway, if there is some alkaloid that is destroyed by soaking in the presence of a little garlic oil. I just hate to see drug lore invented when there's no evidence that cyanide is the source of the nausea. It will just lead to crazy theories about cyanide causing bad trips and kids smearing themselves with garlic paste.

@Scrofula Thank you for the detailed comments. I was not here when this guide was made but have been editing it recently and was not sure about the cyanide/nausea claims. I've changed the wording a little bit to something that might seem more fair? Or do you think the reference to cyanide should be removed completely? Is it fair to call LSA as an unpredictable nausea producing agent? It is not part of my field of expertise. Clarity (talk) 01:05, 2 June 2017 (CEST)

@Clarity Sorry, my notifications were going to my super-sekrit email that I never check, and I'm knew to Wiki editing. Problem is that the whole protocol is based on removing cyanide from the seeds--the author cites "cyanogenic glycosides" and a garlic addition to remove it. I know from experience these seeds will make you retch, hard, and it sounds anecdotally to be predictable, but if that was from cyanide, I'd expect other symptoms too, like death. And then I wonder, how do we know this protocol even works? I guess I'm also too new to know what your guidelines are for posting protocols, so I'll take a look.

@Scrofula: No worries Scrofula! The more I think about this the more I find it fairly unlikely that the garlic-cyanogenic glycosides part actually has scientific validity. I have done an internet search which seems to suggest this is more drug-folklore and placebo-based. If anything, I think just performing the basic extraction itself and the seemingly large range in natural variations in one's response to LSA could just as easily account for the nausea reduction. Personally, I am not in the mood to run any experiments to confirm either way so I am thinking of just reformatting the guide so that it mentions the garlic part as an option that some claim helps. If you have any other ideas or can find evidence that supports either case, please do let me know. Clarity (talk) 06:07, 11 June 2017 (CEST)