Talk:Substituted pyrrolidinophenones

Pyrrolidinophenones are a chemical class releated to cathinones, and they differs from other cathinones in that they contains a pyrrolidine ring in amino group.

Presence of a pyrrolidine ring in any cathinone-like compound confers potent uptake blocking properties at DAT (dopamine transporter) and NET (norepinephrine transporter). Thus, pyrrolidinophenones are mechanistically distinct from ring-substituted cathinones, such as mephedrone and methylone, which act as non-selective substrates for monoamine transporters and trigger transmitter release. Importantly, MDPV and α-PVP are similar in potency and transporter selectivity, indicating that the presence of the 3,4-methylenedioxy substituent in MDPV does not exert much influence on the profile of transporter activity. By contrast, alkyl chain length extending from the α-carbon is a critical structural feature, with shorter chain length (i.e., α-PPP, methyl) yielding less potent transporter-blocking properties when compared to longer chain length (i.e., α-PVP, propyl).^[1]

• Responsible use
• Research chemicals
• Stimulants
• Cathinones

• Pyrrolidinophenone (Wikipedia)