"Under normal conditions, THC appears to passively diffuse from fat back into blood, thus explaining its long elimination half-life. However it is possible that under conditions of enhanced fat metabolism (lipolysis), THC might be released from fat at much higher concentrations than normal."
"We have also received recent anecdotal forensic reports of high THC levels in the blood of ex-cannabis users who have lost significant body weight immediately prior to test sampling. Stress and food deprivation (FD) are reliable promoters of lipolysis, and this can be largely ascribed to activation of the sympathetic nervous system (Meisner and Carter, 1977; Palou et al., 1981; Nonogaki, 2000). Activation of the sympathetic nervous system increases the release of hormones such as adrenaline and adrenocorticotrophic hormone (ACTH), which in turn interact with adipocyte membrane-bound receptors such as β-adrenoceptors and melanocortin receptors (MC) that stimulate hormone-sensitive lipases (HSL) to hydrolyse triglycerides into free fatty acids (FFA) and glycerol (Meisner and Carter, 1977; Langin, 2006)."
"Collectively the data obtained in the present study demonstrate that lipolysis significantly enhances the release of THC from fat tissue resulting in increased levels in the blood. The lipolytic agent ACTH enhanced the release of THC from adipocytes previously treated in vitro with THC. This effect correlated with ACTH-induced lipolysis. Similarly, ACTH enhanced the release of THC from ex vivo adipocytes of rats that were repeatedly pretreated with systemic injections of THC. Complementary in vivo experiments showed that systemic ACTH or 24 h of FD both increased the blood concentrations of THC and its metabolite THC-COOH in rats pretreated in vivo with THC."
^^ From the source I found, if you can find a better one feel free to change it! And thank you for taking the time to check these things out, it's a pretty small group of people making edits and yours are really worthwhile, coherent, and useful (:
P.S. - never wish me opioids, I'm a recovering heroin addict (: I appreciate the sentiment though
