UserWiki:Clarity/Ideapad

"If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it."

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"There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it."

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"The toxicity and long-term health effects of recreational XYZ use do not seem to have been studied in any scientific context and the exact toxic dose is unknown.

This is because XYZ is a research chemical with very little history of human usage. Anecdotal evidence from those within the community who have tried XYZ suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed)."

XYZ is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

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Tolerance to many of the effects of ABCD develops with prolonged and repeated use. This results in users having to administer increasingly larger doses to achieve the same effects. Upon a single administration, it takes about 1 month for the tolerance to be reduced to half and 2.5 months to be back at baseline (in the absence of further consumption). MDMA presents cross-tolerance with all dopaminergic and serotonergic stimulants, meaning that after the consumption of MDMA all stimulants will have a reduced effect.

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Tolerance to many of the effects of ketamine develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Ketamine presents cross-tolerance with all dissociatives, meaning that after the consumption of ketamine all dissociatives will have a reduced effect.

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Tolerance to many of the effects of DCK develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). DCK presents cross-tolerance with all dissociatives, meaning that after the consumption of DCK all dissociatives will have a reduced effect.

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Tolerance to many of the effects of kratom develops with prolonged and repeated use. The rate at which this occurs develops at different rates for different effects, with tolerance to the constipation-inducing effects developing particularly slowly for instance. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Kratom presents cross-tolerance with all other opioids, meaning that after the consumption of kratom all opioids will have a reduced effect.

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2C-E's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

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olerance to many of the effects of cocaine develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption).

Following extensive discussions with Kenan @ PS17 week, taken via phone on the flight back :P

thats some dope shit right here. --Kenan (talk) 04:24, 27 April 2017 (CEST)

• Breakdown all pharmacology sections into "Pharmacokinetics", "Pharmacodynamics" with corresponding "Sci Portal" pages providing both quick + accessible versions as well as comprehensive ones (start with classic psys)
• Add Structure Activity Relationship (SAR) sections to all pages, either as its own section or a subsection of "Chemistry"
• More development of basic biological and pharmacological content that users can access through our descriptions (i.e. Pages like "Synapse", "Postsynaptic Density", "Autoreceptor", "Ionotropic vs GPCRs", "Blood-brain barrier", the different subtypes of monoamine receptors like 5HT2B, 5HT1A, 5HT2A/C, etc)
• More potential user-valued sections like "History and Culture", "Behavioral Toxicity", "Common Myths/Misconceptions and FAQs" etc to increase page/content diversity to differentiate ourselves from other sites
• Reagent Testing Section for commonly adulterated/misrepresented substances.
• Creation of "Recommended Books and Media" section with Amazon affiliate links for shared PW account?
• "Featured article" panel on main page? More indicators of dynamic nature of content development and a sense of an editorial board.
• Feature contraindications and dangerous interactions more prominently/visibly i.e. Tripsit
• Standardize "Physical Effects" to ground them in a medical framework.
• Automatically reiteratable substanceboxes that uses mathematical algorithms to calculate different doses based on salt form.
• Anonymous feedback links under each SubstanceBox?
• Upgrade forum to more modern, user alluring one. Then have it more directly integrated into the pages so users who are afraid to edit have a gateway to providing feedback and input (will also encourage more active participation from userbase who have the potential to become contributors but currently aren't due to intimidation factor)
• Autofill Summary boxes based on sections edited, then require editors to provide summaries
• Red/yellow/green strips or some other indicator above substanceboxes denoting "novelty" or "verified information" or "page reliability" form? To help sort out truly novel RCs which don't have any scientific literature produced on them vs. those produced through literature mining and have a higher or lower speculated risk of unpredictable effects based on Structure-Activity Relationship analysis.
• PubChem as reference to all IUPAC and systematic names
• "Announcements" or "Bulletin" pages for editors to see new content initiatives/guidelines.
• Partner with EnergyControl or other drug analysis service to link to on our pages for commonly counterfeited/adulterated substances.
• highlight search box main result with translucent blue panel for increased visibility?
• Change psychedelic tolerance baselines to the standard online "two week" chart
• Boilerplate basic coverage of all basic RC psychs w/tags to cite incompleteness?
• Monthly high scores? "Featured User" Panel on Mainpage, etc.
• "Common drug myths" and FAQs page to clear basic misconceptions userbase may have, ranging from basic to nuanced.
• Further development of PW style and formatting standards
• Citation conversion guide?
• PW t-shirt line of "Drug Molecules" print? (collective fund) (i like this :D --Corticosteroid (talk) 07:24, 20 August 2017 (CEST))
• Start development of basic "philosophy of mind" sections?
• More collaboration with Global Psychedelics Network?
• Start development of monthly newsletter/newsfeed on Psynthes.is?
• Change "Legal issues" to "Legality" so as to not imply inherent illegality?
• "History of Prohibition" page (start with alcohol?)