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Anhedonia is generally considered to have the inability to feel joy or happiness due to either complete dopamine depletion (the main prolific neurotransmitter) caused by either a natural medical conditions such as Schizophrenia or Parkinson's Disease.
The most common ways Anhedonia can manifest itself is through prolonged usage of Dopaminergic Stimulants such as Methamphetamine, Substituted Cathinones, or Substituted Amphetamines.