Nicotine/Summary

Main article: Nicotine

Psychoactive class: Stimulants, Depressant

Chemical class: Pyridine, Substituted pyrrolidines

Oral

Thresh Common Heavy

0.2 - 1 - 3 - 5 - 7 mg

Light Strong
- Total: 5 - 7 hours
- Onset: 20 - 40 minutes
- Come up: 60 - 90 minutes
- Peak: 60 - 90 minutes
- Offset: 2.5 - 3.5 hours
- Afterglow: 2 - 4 hours

Buccal

Thresh Common Heavy

0.2 - 0.5 - 2 - 4 - 6 mg

Light Strong
- Total: 45 - 90 minutes
- Onset: 3 - 15 minutes
- Come up: 3 - 15 minutes
- Peak: 5 - 20 minutes
- Offset: 1 - 2 hours
- Afterglow: 2 - 6 hours

Smoked

Thresh Common Heavy

0.2 - 0.3 - 0.8 - 1.5 - 3.5 mg

Light Strong
- Total: 1 - 3 hours
- Onset: 5 - 20 seconds
- Come up: 5 - 10 seconds
- Peak: 2 - 5 minutes
- Offset: 1 - 2 hours
- Afterglow: 1 - 3 hours

Harm potential

- Extremely addictive with a high potential for abuse
- Estimated oral LD₅₀ of 6.5 - 13 mg/kg in humans

Tolerance

- Full tolerance is reached rapidly develops with prolonged and repeated use
- Decreases to half after 3 - 7 days
- Returns to baseline after 1 - 2 weeks

See also

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