Depressant - PsychonautWiki



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Pictured above are bottles of alcohol, the most common depressant.

Depressants (also known as sedatives and informally as "downers") are a major class of psychoactive substances that decreases activity in the brain through the lowering of neurotransmission levels, depressing or reducing arousal/stimulation in various areas of the brain.[1] Depressants represent one of the three major classes of psychoactive substances alongside stimulants ("uppers") and hallucinogens.

Depressants are widely used throughout the world as prescription medicine and as illicit substances. Subjective effects can vary but generally include sedation, anxiety suppression, disinhibition, muscle relaxation, and euphoria. Side effects include decreased blood pressure, lowered heart rate, respiratory depression, and even complete anesthesia or death at high doses.

Depressants exert their effects through a number of different pharmacological mechanisms. The most prominent include the facilitation of GABA or opioid activity and the inhibition of glutamatergic or catecholaminergic activity.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on collected anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce a full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death ☠.

These effects are listed and described in detail within their own dedicated articles below:


The chemicals below have varying degrees of typical depressant effects.


See also

External links