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Fatal overdose may occur when benzodiazepines are combined with other depressants such as opiates, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1]
It is strongly discouraged to combine these substances, particularly in common to heavy doses.
| Summary sheet: Bromazepam |
| Bromazepam | |||||||||||||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||||||||||||
| Common names | Bromazepam, Brozam, Lectopam, Lexomil, Lexotan, Lexilium, Lexaurin, Brazepam, Rekotnil, Bromaze, Somalium, Lexatin, Calmepam, Zepam, Lexotanil | ||||||||||||||||||||||||||||||||
| Substitutive name | Bromazepam | ||||||||||||||||||||||||||||||||
| Systematic name | 7-Brom-5-pyridin-2-yl-1,3-dihydrobenzo[e][1,4]diazepin-2 | ||||||||||||||||||||||||||||||||
| Class Membership | |||||||||||||||||||||||||||||||||
| Psychoactive class | Depressant | ||||||||||||||||||||||||||||||||
| Chemical class | Benzodiazepine | ||||||||||||||||||||||||||||||||
| Routes of Administration | |||||||||||||||||||||||||||||||||
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| Interactions | |||||||||||||||||||||||||||||||||
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects 
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- Sedation - In terms of energy level alterations, this drug is considerably unique in that it tends to be notably less sedating and less inebriating than other classical or standard benzodiazepines such as alprazolam, clonazepam, and lorazepam. In some sense, it may be seen by many users as more “relaxing” in terms of description rather than being thoroughly “sedating” in average doses (10 - 15mg). However, at sufficient enough doses sedation does become a salient and unavoidable effect at a certain point. Therefore, presumably at stronger doses this causes users to feel extreme somnolence, forcing them to sit down as they tend to generally feel as if they are constantly on the verge of passing out instead of being physically mobile or consciously alert. This component increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.
- Muscle relaxation - In comparison to alprazolam (Xanax), bromazepam results in a greater degree of muscle relaxation.
- Motor control loss
- Respiratory depression
- Dizziness - This symptom is usually much less prevalent compared to typical, (“heavier”) benzodiazepines like clonazepam or lorazepam.
- Seizure suppression
- Physical euphoria
Visual effects 
Paradoxical effects 
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Paradoxical reactions to benzodiazepines such as increased seizures (in epileptics), aggression, increased anxiety, violent behavior, loss of impulse control, irritability and suicidal behavior sometimes occur (although they are rare in the general population, with an incidence rate below 1%).[2][3]
These paradoxical effects occur with greater frequency in recreational abusers, individuals with mental disorders, children, and patients on high-dosage regimes.[4][5]
Cognitive effects 
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The most prominent of these cognitive effects generally include:
- Anxiety suppression - Less pronounced than with alprazolam, especially in regards to panic attacks but may have an upper-hand on many other benzodiazepines in this department due to a very lightly euphoric and subtle, but not uncommon comfortable sense of well-being that is not usually associated with other benzodiazepines.
- Disinhibition
- Delusions of sobriety - This is the false belief that one is perfectly sober despite obvious evidence to the contrary such as severe cognitive impairment and an inability to fully communicate with others. It most commonly occurs at heavy dosages.
- Thought deceleration
- Analysis suppression
- Amnesia
- Memory suppression
- Increased music appreciation
- Compulsive redosing
- Emotion suppression
- Motivation suppression
- Language suppression - Bromazepam & most benzodiazepines are known to cause slurred speech and difficulty communicating words in a clear fashion.
After effects 
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- Rebound anxiety - Rebound anxiety is a commonly observed effect with anxiety relieving substances like benzodiazepines. It typically corresponds to the total duration spent under the substance's influence along with the total amount consumed in a given period, an effect which can easily lend itself to cycles of dependence and addiction.
- Dream potentiation[6] or Dream suppression
- Residual sleepiness - While benzodiazepines can be used as an effective sleep-inducing aid, their effects may persist into the morning afterward, which may lead users to feeling "groggy" or "dull" for up to a few hours.
- Thought deceleration
- Thought disorganization
- Irritability
Toxicity and harm potential
Bromazepam has a low toxicity relative to dose. However, it is potentially lethal when mixed with depressants like alcohol or opioids.
It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the administration of the intended dose.
Lethal dosage
Depends on the Individual
Tolerance and addiction potential
Strong Physical and Psychological addiction potential
Dangerous interactions
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before= consumption.
- Depressants (1,4-Butanediol, 2-methyl-2-butanol, alcohol, barbiturates, GHB/GBL, methaqualone, opioids) - This combination can result in dangerous or even fatal levels of respiratory depression. These substances potentiate the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
- Dissociatives - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
- Stimulants - It is dangerous to combine benzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects. If combined, one should strictly limit themselves to only dosing a certain amount of benzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.
Legal status
Internationally, bromazepam is a Schedule IV controlled drug under the Convention on Psychotropic Substances.[7] Bromazepam is regulated in most countries as a prescription drug.
See also
External links
References
- ↑ Risks of Combining Depressants - TripSit
- ↑ Saïas, T., Gallarda, T. (September 2008). "[Paradoxical aggressive reactions to benzodiazepine use: a review]". L’Encephale. 34 (4): 330–336. doi:10.1016/j.encep.2007.05.005. ISSN 0013-7006.
- ↑ Paton, C. (December 2002). "Benzodiazepines and disinhibition: a review". Psychiatric Bulletin. 26 (12): 460–462. doi:10.1192/pb.26.12.460. ISSN 0955-6036.
- ↑ Bond, A. J. (1 January 1998). "Drug- Induced Behavioural Disinhibition". CNS Drugs. 9 (1): 41–57. doi:10.2165/00023210-199809010-00005. ISSN 1179-1934.
- ↑ Drummer, O. H. (February 2002). "Benzodiazepines - Effects on Human Performance and Behavior". Forensic Science Review. 14 (1–2): 1–14. ISSN 1042-7201.
- ↑ Goyal, S. (14 March 1970). "Drugs and dreams". Canadian Medical Association Journal. 102 (5): 524. ISSN 0008-4409.
- ↑ International Narcotics Control Board (2003) | http://infoespai.org/wp-content/uploads/2014/12/green.pdf