|Summary sheet: Risperidone|
|Routes of Administration|
Risperidone (also known as Risperdal) is an atypical antipsychotic medication of the benzisoxazole chemical class. Risperidone is prescribed for bipolar disorder, autism, and psychotic disorders, such as in schizophrenia. It is sometimes used as a sedative to reduce the effects of psychedelics like LSD and to induce sleepiness. Benzodiazepines are also used for this purpose.
Risperidone has a complex pharmacology, but its main mechanism of action is as a D2 dopaminergic receptor antagonist. This means that it blocks dopamine from binding to the receptor, meanwhile not activating it. It also blocks most of the serotonin receptors, being an inverse agonist at the 5-HT2A, 5-HT2B, and 5-HT2C serotonin receptors. Risperidone has the strongest affinity to the 5-HT2A receptor. On top of that, it acts as an irreversible antagonist at the 5-HT7 serotonin receptor. Its hypnotic effects come from the blockade of dopamine D2 receptors.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death.
- Appetite enhancement
- Sedation - Risperidone produces strong sedation and can result in an overwhelmingly lethargic state. At higher levels, risperidone can cause users to suddenly feel as if they are extremely sleep deprived and have not slept for days, forcing them to sit down and generally feel as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.
- Decreased libido
- Increased heart rate
- Motor control loss
- Nausea suppression
- Weight gain
- The general head space of risperidone is often described as one of sleepiness, emptiness, apathy, stupor and catatonia. The specific cognitive effects can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Toxicity and harm potential
- Australia: Risperidone is available only through prescription.
- Germany: Risperidone is a prescription medicine, according to Anlage 1 AMVV.
- Switzerland: Risperidone is listed as a "Abgabekategorie B" pharmaceutical, which requires a prescription.
- United Kingdom: Risperidone is available only through prescription.
- United States: Risperidone is available only through prescription.
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