Talk:Fluoxetine

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Summary sheet: Fluoxetine

Chemical Nomenclature

Common names

Fluoxetine, Prozac

Systematic name

N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine

Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions

Fluoxetine is an antidepressant substance of the selective serotonin reuptake inhibitor (SSRI) class. It is a widely prescribed psychiatric medication used in the treatment of depression, obsessive compulsive disorder, and bulimia nervosa.^{[citation needed]}

It is worth noting that antidepressants like fluoxetine have limited recreational potential. They may also reduce the action of certain serotonergic substances such as psychedelics and entactogens.

Individuals who are prescribed SSRIs that seek to use hallucinogenic substances for psychonautic or recreational purposes are advised to research potential interactions beforehand. It is usually advised to taper off any SSRIs before engaging in hallucinogen use.

Pharmacology

Fluoxetine acts by inhibiting the presynaptic reuptake of the neurotransmitter serotonin, resulting in higher levels of 5-hydroxytryptamine (5-HT) in various areas of the brain.

It is 5-HT selective due to its high affinity for 5-HT transporters, weak affinity for noradrenaline transporters and lack of affinity for dopamine transporters.^[1]

Among approved antidepressants, fluoxetine may be less effective than newer agents such as escitalopram.^[2] However, its very long elimination half-life of 1–3 days (acute) and 4–6 days (chronic)^[3] makes it attractive as a treatment for SSRI withdrawal symptoms.^[4]

Subjective effects

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Experience reports

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Erowid Experience Vaults: Fluoxetine

Toxicity and harm potential

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Note: Always conduct independent research and use harm reduction practices if using this substance.

External links

References

↑ Fluoxetine, DrugBank
↑ Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. (April 2018). "Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis". Lancet. 391 (10128): 1357–1366. doi:10.1016/S0140-6736(17)32802-7. PMC 5889788  . PMID 29477251.
↑ Altamura AC, Moro AR, Percudani M (March 1994). "Clinical pharmacokinetics of fluoxetine". Clinical Pharmacokinetics. 26 (3): 201–14. doi:10.2165/00003088-199426030-00004. PMID 8194283. Unknown parameter |s2cid= ignored (help)
↑ . doi:10.1017/S1461145708008493  . Missing or empty |title= (help)

[1] Fluoxetine, DrugBank

[pmid29477251-2] Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. (April 2018). "Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis". Lancet. 391 (10128): 1357–1366. doi:10.1016/S0140-6736(17)32802-7. PMC 5889788  . PMID 29477251.

[PK-3] Altamura AC, Moro AR, Percudani M (March 1994). "Clinical pharmacokinetics of fluoxetine". Clinical Pharmacokinetics. 26 (3): 201–14. doi:10.2165/00003088-199426030-00004. PMID 8194283. Unknown parameter |s2cid= ignored (help)

[4] . doi:10.1017/S1461145708008493  . Missing or empty |title= (help)

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