Talk:Olanzapine

Summary sheet: Olanzapine

Chemical Nomenclature

Common names

Olanzapine, Zyprexa

Systematic name

2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

Class Membership

Psychoactive class

Antipsychotic

Chemical class

Thienobenzodiazepine

Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

⇣ Oral
Dosage
Bioavailability	60 - 65%^[1]
Threshold	1 mg
Light	2.5 - 5 mg
Common	5 - 10 mg
Strong	10 - 15 mg
Heavy	15 mg +
Duration
Total	6 - 8 hours
Onset	40 - 60 minutes
Peak	1.5 - 6 hours
Offset	8 - 12 hours
After effects	20 - 24 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions

Olanzapine, first branded as Zyprexa, is a widely-used antipsychotic substance of the thienobenzodiazepine chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine can be given by mouth and can also be injected into a muscle. Olanzapine might be useful as a trip aborter, especially for stimulants, as it blocks the action of dopamine. ^{[citation needed]}

Chemistry

Olanzapine is a thienobenzodiazepine. It includes a piperazine moiety at R₄.

Pharmacology

Olanzapine is known to cause weight gain and induce diabetes mellitus type 2 more frequently than other antipsychotics. However, it is less likely to produce tardive dyskinesia or an extrapyramidal reaction. It appears to be an effective treatment for schizophrenia.^[2]

Subjective effects

Physical effects

- Hunger - This often happens over a course of treatment and not with one use.
- Sedation - This effect is more often uncomfortably tiring than relaxing.
- Salivation
- Muscle relaxation
- Motor control loss
- Dizziness
- Perception of bodily heaviness
- Headaches
- Extrapyramidal symptoms

Cognitive effects

- Anxiety suppression - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and antiserotonergic action rather than GABA-related activity.
- Emotionality suppression - Olanzapine dulls and suppresses emotions.
- Focus suppression or enhancement - This often depends on the mental state of the individual.
- Decreased libido
- Sleepiness
- Cognitive euphoria - This effect is extremely rare. Olanzapine is often a dulling, "boring" pharmaceutical.
- Cognitive dysphoria - This often includes a sense of boredom or depression accompanied by uncomfortable sedation.

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Erowid Experience Vaults: Olanzapine

External links

References

↑ https://doi.org/10.2165%2F00003088-200746050-00001
↑ Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.

[1] ttps://doi.org/10.2165%2F00003088-200746050-00001

[2] Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.

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