Cabergoline - PsychonautWiki



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The structure of cabergoline

Cabergoline is a chemical of the lysergamide and ergopeptine classes. It is a close derivative of LSD, or more specifically, AL-LAD, but instead shares many effects with related, non-psychedelic medicinal compounds such as ergotamine, ergonovine or lisuride. It is occasionally prescribed to treat symptoms of high prolactin levels and managing Parkinson's disease.

Cabergoline is not predominantly psychedelic, it mainly exerts its effects at the dopamine D2 receptor as an agonist but has comparatively little effect on the serotonin 5-HT2A receptor where it acts as a partial agonist.

Cabergoline has little recreational value other than its unique property of reducing or eliminating the male refractory period, thereby allowing men to experience multiple ejaculatory orgasms in rapid succession.[1][2]

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  1. Krüger, T. H. C., Haake, P., Haverkamp, J., Krämer, M., Exton, M. S., Saller, B., Leygraf, N., Hartmann, U., Schedlowski, M. (December 2003). "Effects of acute prolactin manipulation on sexual drive and function in males". The Journal of Endocrinology. 179 (3): 357–365. doi:10.1677/joe.0.1790357. ISSN 0022-0795. 
  2. Hollander, A. B., Pastuszak, A. W., Hsieh, T.-C., Johnson, W. G., Scovell, J. M., Mai, C. K., Lipshultz, L. I. (March 2016). "Cabergoline in the Treatment of Male Orgasmic Disorder-A Retrospective Pilot Analysis". Sexual Medicine. 4 (1): e28–33. doi:10.1016/j.esxm.2015.09.001. ISSN 2050-1161.