Fluoxetine - PsychonautWiki



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Fluoxetine is an antidepressant substance of the selective serotonin reuptake inhibitor (SSRI) class. It is a widely prescribed psychiatric medication used in the treatment of depression, obsessive compulsive disorder, and bulimia nervosa.[citation needed]

It is worth noting that antidepressants like fluoxetine have limited recreational potential. They may also reduce the action of certain serotonergic substances such as psychedelics and entactogens.

Individuals who are prescribed SSRIs that seek to use hallucinogenic substances for psychonautic or recreational purposes are advised to research potential interactions beforehand. It is usually advised to taper off any SSRIs before engaging in hallucinogen use.


Fluoxetine acts by inhibiting the presynaptic reuptake of the neurotransmitter serotonin, resulting in higher levels of 5-hydroxytryptamine (5-HT) in various areas of the brain.

It is 5-HT selective due to its high affinity for 5-HT transporters, weak affinity for noradrenaline transporters and lack of affinity for dopamine transporters.[1]

Subjective effects

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Toxicity and harm potential


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Note: Always conduct independent research and use harm reduction practices if using this substance.


  1. Fluoxetine, DrugBank