Talk:Amisulpride - PsychonautWiki

Talk:Amisulpride

Active discussions
Yellow-warning-sign1.svg

This page has not been fully approved by the PsychonautWiki administrators.

It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.

Summary sheet: Amisulpride
Amisulpride
Amisulpride.svg
Chemical Nomenclature
Common names Amisulpride, Solian, Barhemsys
Systematic name 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
Class Membership
Psychoactive class Antipsychotic
Chemical class Benzamide
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Bioavailability 48%
Threshold 25 mg
Light 50 - 100 mg
Common 100 - 200 mg
Strong 200 - 300 mg
Heavy 300 mg +
Duration
Total 12 - 24 hours
Onset 20 - 40 minutes
Peak 1.5 - 6 hours
Offset 8 - 12 hours
After effects 24 - 48 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions

Amisulpride (also known under brand names including Solian and Barhemsys) is a atypical antipsychotic substance of the benzamide class.

History and culture

 

This History and culture section is a stub.

As a result, it may contain incomplete or wrong information. You can help by expanding it.

Chemistry

 

This chemistry section is incomplete.

You can help by adding to it.

Amisulpride is the 4-position amino substitution of sulpiride which in turn is based on a benzamide core.

Pharmacology

Amisulpride primarily works by antagonising D2 and D3 dopamine receptors aswell as the 5-HT7, 5-HT2A and 5-HT2B serotonin receptors.

It is also known to act as a GHB receptor agonist and Mu- Delta- Kappa-opioid agonist[1]

Subjective effects

 
This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
 

Cognitive effects
 

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Toxicity and harm potential

 

This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Dangerous interactions

 

This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

 

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Australia: Amisulpride is a Schedule 4 prescription only drug.[citation needed]
  • Brazil: Amisulpride is a Class C1 prescription only drug.[2]
  • United Kingdom: Amisulpride is a prescription only drug.[3]
  • United States: Amisulpride is a prescription only drug.[citation needed]

See also

External links

References

  1. Rehni AK, Singh TG, Chand P: Amisulpride-induced seizurogenic effect: a potential role of opioid receptor-linked transduction systems. Basic Clin Pharmacol Toxicol. 2011 May;108(5):310-7. doi: 10.1111/j.1742-7843.2010.00655.x. Epub 2010 Dec 22. (PubMed ID 21176108)
  2. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992
  3. https://web.archive.org/web/20200226225750/https://www.medicines.org.uk/emc/product/2726/smpc
Return to "Amisulpride" page.