Talk:Ecgetrin

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Not to be confused with Ecotrin.
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Summary sheet: Ecgetrin
Chemical structure

Ecgetrin (also known as Ecgedetrine) is new synthetic tropane alkaloid stimulant that is similar to Cocaine but lacks any distinguishable physical side effects associated with Cocaine, yet it still slightly increases heart rate. It is of the substituted tropanes class. Ecgetrin is an dopamine reuptake inhibitor and is structurally related to Troparil and while it has stimulating effects on the CNS, Ecgetrin, as a Troparil or desoxyphenyl type tropane compound (2,5-diethoxy phenyl-methyl tropane-2-acetyllethane) is reported to not effect the sympathetic nervous system in the same way benzoyl tropanes historically have been. It in general is a more balanced reuptake inhibitor, potentially with affinity as an agonist ligand of serotonin and dopamine because of the ethoxy ether moities in its internal structure, as well as the less acidic nature of the ethylcarboxyl moiety at the tropane 2-position, more common in agonists versus reuptake inhibitors. Also, because the serotonin-dopamine activity is more at balance with Ecgetrin than other tropane stimulants and it does not have a high reactivity with most ions it is generally, of non-esterified aromatic tropanes thus less likely to cause adverse or specific physical body loads or abnormal physical sensations or experiences.


History and culture

 

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Chemistry

 

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Pharmacology

 

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Subjective effects

Ecgetrin is reported to have a much more rapid onset and lower half-life when vaporized or smoked. Intranasal


 
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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
 

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Experience reports

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Toxicity and harm potential

 

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Note: Always conduct independent research and use harm reduction practices if using this substance.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Dangerous interactions

 

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Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

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References


Synthesis

-=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=- -=~=- -=~=- -=~=- -=~=- ECGETRIN -=~=- -=~=- -=~=- -=~=- -=~=- -=~=- 2,5- DIMETHOXYPHENYLMETHYL 1-TROPANYL-2- ETHYLACETATE -=~=- -=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=--=~=-

(mol = ratio of one molecule to the rest of the ingredients, scalar)

(STIR BETWEEN EACH STEP 5-10MIN)

-=~=- -=~=- -=~=- This synthetic procedure for Ecgetrin

involves cheap generally nontoxic or FDA-approved

unregulated ingredients-=~=- -=~=- -=~=-

-=~=- -=~=- -=~=--=~=- -=~=- -=~=--=~=- -=~=- -=~=-

-=~=- -=~=- -=~=--=~=- -=~=- -=~=--=~=- -=~=- -=~=-

STEP 1.

add 1mol benzyl alcohol (hydroxymethyl benzene), 2mol ethanol and 2mol acetic acid

(if you are using sodium or alkali ethers or reducible esters such as methoxide,

skip aceticacid mixture addition), stir

STEP 2.

add 1mol ammonium chloride, stir

STEP 3.

add 1mol sodium carbonate (or bicarbonate if acid esters are formed from acetate etc.)

(OR 1/2mol sodium methyl/ethyl oxide now INSTEAD, if no ethanol and acetic acid), stir well

STEP 4.

add 1mol ammonium chloride again, stir

STEP 5.

add 1mol sodium carbonate (or bicarbonate if acid esters are formed from acetate etc.)

(OR 2/2mol sodium methyl/ethyl oxide now INSTEAD, if no ethanol and acetic acid), stir well

STEP 6.

add 1mol cyclohexanone

add 2mol acetic acid

add 1mol isopropanol

add 1mol ethanol

stir

STEP 7.

add 0.75mol MgSO4 Epsom salts (1mol if you added alkali ethers or esters), STIR WELL

STEP 8.

add 1.5mol ammonium chloride, stir well

STEP 9.

add up to the 6mol water H2O

(or just same number ml as the liquids approx.)

STEP 10.

add 1mol sodium carbonate, stir well

STEP 11.

add 1mol ammonium chloride

stir well

step 12.

-> ecgetrin

(+ sulfur gases / maybe some sulfate if water present?)

-=~=- -=~=- -=~=--=~=- -=~=- -=~=--=~=- -=~=-

forming the HCL,

you can add 1mol extra ammonium chloride with 5mol water and get the hcl

-=~=- -=~=- -=~=- -=~=-

another way to make 2,5 diethoxy BzOH/ 2,5 diacetyl BzOH :

formed by the end of step 5, is by adding iron out powder (1mol% sodium metabisulfite,

2mol% sodium sulfite) so there are 2:1 + 1:1 for 3:1 moles of salts to alcohol,

then reducing phenols and the 14% ethanol in witch hazel on benzyl alcohol, added in

that order in water... the phenols reduce the ethoxy in place and produce SO2/SO3 gas

and instantly get 2,5 diethoxy benzyl alcohol.

(witch hazel 14% ethanol can also be used to directly acetylethylate the tropane 2-

acetate)

-=~=- -=~=- -=~=--=~=- -=~=- -=~=--=~=- -=~=- -=~=-

-=~=- -=~=- -=~=--=~=- -=~=- -=~=--=~=- -=~=- -=~=-

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