Talk:Magnolia
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| Summary sheet: Magnolia |
Template:SubstanceBox/Honokiol
Not sure if this substance/botany entry would be best suited as "Magnolia", "Magnolia bark", "Magnolia officinalis", "Magnolol", "Honokiol", or another title. Both modern and historical anecdotal evidence as well as a substantial body of scientific literature supports the psychotropic potential and pharmacological bioactivity of alkaloids in the bark of Magnolia species. Although it is undoubtedly less psychoactive than many of the plant species described on this wiki, it is also notably more active than many other OTC plant-based health supplements, and can produce noticeable acute changes in perception and consciousness with reasonable doses, without the need for the advanced extraction methods necessary to render many botanical compounds sufficiently bioavailable to produce substantial effects.
History and culture
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This History and culture section is a stub. As a result, it may contain incomplete or wrong information. You can help by expanding it. |
Chemistry
Magnolia Bark contains two main psychoactive compounds, Honokiol and Magnolol, which belongs to a class of neolignan biphenols. Honokiol and Magnolol are positional isomers, only differing by the position of one Hydroxyl group. They are hydrophobic and readily dissolved in lipids.
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This chemistry section is incomplete. You can help by adding to it. |
Pharmacology
It is believed that honokiol acts on GABAA receptors similarly to benzodiazepines and Z-drugs. However, honokiol has been shown to achieve anxiolysis with fewer motor or cognitive side effects than GABAA receptor agonists such as flurazepam and diazepam. It has been shown that honokiol likely has a higher selectivity for different GABAA receptor subtypes and both magnolol and honokiol showed higher efficacy when acting on receptors containing δ subunits. GABAA receptors control ligand-gated Cl− channels that can help increase seizure thresholds through the influx of chloride anions. Honokiol may also affect the synthesis of GABA. In a study where mice received seven daily injections of honokiol, researchers observed a mild increase in hippocampal levels of glutamate decarboxylase (GAD67) an enzyme that catalyzes the synthesis of GABA. However, the increase was within the margin of error for the method used to quantify the protein. Honokiol and magnolol have also been found to act as agonists at the cannabinoid receptors with significant affinity for the CB2 receptor.
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This pharmacology section is incomplete. You can help by adding to it. |
Subjective effects
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This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it. |
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects 
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- Sedation
- Pain relief
- Muscle relaxation
- Physical euphoria
- Mouth numbing - Sufficiently potent magnolia bark produces a numbing sensation on the tongue and gums when consumed as a tea.
- Tactile suppression
- Gustatory suppression - When consumed as tea, but not as capsules - suggests a local blocking effect on signalling from taste buds
Visual effects 
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Enhancements
Cognitive effects 
Experience reports
There are currently 0 experience reports which describe the effects of this substance in our experience index.
Additional experience reports can be found here:
Toxicity and harm potential
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This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. |
It is strongly recommended that one use harm reduction practices when using this substance.
Lethal dosage
Tolerance and addiction potential
Dangerous interactions
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This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it. |
Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Legal status
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This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
See also
External links
(List along order below)
- SUBSTANCE (Wikipedia)
- SUBSTANCE (Erowid Vault)
- SUBSTANCE ([PiHKAL or TiHKAL] / Isomer Design)
Literature
- APA formatted reference
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