Talk:Sulpiride

https://en.wikipedia.org/wiki/Sulpiride

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Summary sheet: Sulpiride

Sulpiride

Chemical Nomenclature

Common names

DMT, Dimethyltryptamine, Dmitri

Substitutive name

N,N-Dimethyltryptamine

Systematic name

2-(1H-Indol-3-yl)-N,N-dimethylethanamine

Class Membership

Psychoactive class

Psychedelic

Chemical class

Tryptamine

Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

⇣ Oral
Dosage
Bioavailability	x% - y%^[1]
Threshold	x - mg
Light	x - y mg
Common	x - y mg
Strong	x - y mg
Heavy	x mg +
Duration
Total	x - y hours
Onset	x - y minutes
Come up	x - y minutes
Peak	x - y hours
Offset	x - y hours
After effects	x - y hours

⇣ Sublingual
Dosage
Bioavailability	x% - y%
Threshold	x - mg
Light	x - y mg
Common	x - y mg
Strong	x - y mg
Heavy	x mg +
Duration
Total	a - b hours
Onset	a - b minutes
Come up	a - b minutes
Peak	a - b hours
Offset	a - b hours
After effects	a - b hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Dogmatil,Eglonyl

History and culture

This History and culture section is a stub.

As a result, it may contain incomplete or wrong information. You can help by expanding it.

Talk:Sulpiride, sold under the brand name Dogmatil among others, is an atypical antipsychotic (although some texts have referred to it as a typical antipsychotic)[10] medication of the benzamide class which is used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and is sometimes used in low dosage to treat anxiety and mild depression. Sulpiride is commonly used in Asia, Central America, Europe, South Africa and South America. Levosulpiride is its purified levo-isomer and is sold in India for similar purposes. It is not approved in the United States, Canada, or Australia. The drug is chemically and clinically similar to amisulpride.

Chemistry

This chemistry section is incomplete.

You can help by adding to it.

Sulpiride is a member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine. It has a role as an antidepressant, an antiemetic, an antipsychotic agent and a dopaminergic antagonist.

Pharmacology

This pharmacology section is incomplete.

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Sulpiride is a selective antagonist at dopamine D2, D3 and to a lesser extent D4 receptors. Antagonism at 5-HT1A dominates in doses exceeding 600 mg daily. In doses of 600 to 1,600 mg sulpiride shows mild sedating and antipsychotic activity. Its antipsychotic potency compared to chlorpromazine is only 0.2 (1/5). In low doses (in particular 50 to 200 mg daily) its prominent feature is antagonism of presynaptic inhibitory dopamine and serotonin receptors, accounting for some antidepressant activity and a stimulating effect. Additionally, it alleviates vertigo.

The benzamide neuroleptics (including sulpiride, amisulpride, and sultopride) have been shown to activate the endogenous gamma-hydroxybutyrate receptor in vivo at therapeutic concentrations.[34] Sulpiride was found in one study in rats to upregulate GHB receptors.[35] GHB has neuroleptic properties and it is believed binding to this receptor may contribute to the effects of these neuroleptics.

Sulpiride, along with clozapine, and valproate has been found to activate DNA demethylation in the brain.[36]

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

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- Physical effect
- Physical effect2
- Physical effect3

Visual effects

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Enhancements
- Visual acuity effect1
Distortions
- Visual distortion effect1
Geometry

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Hallucinatory states

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- Hallucinatory states1

Cognitive effects

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- Cognitive effect1
- Cognitive effect2
- Cognitive effect3

Auditory effects

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- Auditory effect1
- Auditory effect2

Multi-sensory effects

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- Multisensory effect1
- Multisensory effect2

Transpersonal effects

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- Transpersonal effect1
- Transpersonal effect2

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index. Additional experience reports can be found here:

Erowid Experience Vaults: SUBSTANCE

Toxicity and harm potential

This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Dangerous interactions

This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

External links

(List along order below)

SUBSTANCE (Wikipedia)
SUBSTANCE (Erowid Vault)
SUBSTANCE ([PiHKAL or TiHKAL] / Isomer Design)

Literature

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References

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Summary sheet: Sulpiride

Chemical Nomenclature

Common names

DMT, Dimethyltryptamine, Dmitri

Substitutive name

N,N-Dimethyltryptamine

Systematic name

2-(1H-Indol-3-yl)-N,N-dimethylethanamine

Class Membership

Psychoactive class

Psychedelic

Chemical class

Tryptamine

Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

⇣ Oral
Dosage
Bioavailability	x% - y%^[1]
Threshold	x - mg
Light	x - y mg
Common	x - y mg
Strong	x - y mg
Heavy	x mg +
Duration
Total	x - y hours
Onset	x - y minutes
Come up	x - y minutes
Peak	x - y hours
Offset	x - y hours
After effects	x - y hours

⇣ Sublingual
Dosage
Bioavailability	x% - y%
Threshold	x - mg
Light	x - y mg
Common	x - y mg
Strong	x - y mg
Heavy	x mg +
Duration
Total	a - b hours
Onset	a - b minutes
Come up	a - b minutes
Peak	a - b hours
Offset	a - b hours
After effects	a - b hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

For tips on how to properly format a substance article, please refer to this document: Content Style Guide - Substance

History and culture

Sulpiride, sold under the brand name Dogmatil among others, is an atypical antipsychotic (although some texts have referred to it as a typical antipsychotic)medication of the benzamide class which is used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and is sometimes used in low dosage to treat anxiety and mild depression. Sulpiride is commonly used in Asia, Central America, Europe, South Africa and South America. Levosulpiride is its purified levo-isomer and is sold in India for similar purposes. It is not approved in the United States, Canada, or Australia. The drug is chemically and clinically similar to amisulpride. {{historyStub}Sulpiride is marketed under the brand names Dogmatil (DE, HK, SG, PH), Dolmatil (IE, UK, NL), Eglonyl (RU, ZA, HR, SI), Espiride (ZA), Modal (IL), Prometar (UY), Equilid (BR) and Sulpor (UK),Eglonyl(SRB,SLO,CRO,BIH) among many others.}Sulpiride was discovered in 1966 as a result of a research program by Justin-Besançon and C. Laville at Laboratoires Delagrange who were working to improve the anti-dysrhythmic properties of procainamide; the program led first to metoclopramide and later to sulpiride. Laboratoires Delagrange was acquired by Synthelabo in 1991 which eventually became part of Sanofi.

Chemistry

This chemistry section is incomplete.

You can help by adding to it.

Pharmacology

This pharmacology section is incomplete.

You can help by adding to it.

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.