25x-NBOH - PsychonautWiki


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Members of the NBOH series can easily be fatal at higher doses.

It is strongly discouraged to take high doses of these substances or to insufflate (snort) them. Please see this section for more details.

The general structure for a 25x-NBOH compound

25x-NBOH refers to the general form of the NBOH series of psychedelic phenethylamines. It is closely related to the better known 25x-NBOMe series.

The members of the 25x-NBOH series are generally slightly less potent and have a shorter duration than their NBOMe counterparts. Anecdotal evidence suggests minor differences in the physical and subjective effects between the two series.

For example, members of the 25x-NBOH are reportedly more favorable than their NBOMe counterpart in terms of their appreciable body-load. This may be due to the possibility that they are less well absorbed, as they otherwise have similar binding affinities.[citation needed]

The series has little or no history of human use prior to 2012 when NBOMe analogs became available for purchase from online research chemical vendors.

List of 25x-NBOH compounds

Compound R4 Structure
25B-NBOH Br  
25C-NBOH Cl  
25I-NBOH I  
25D-NBOH CH3  

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

Tolerance and addiction potential

Members of the 25x-NBOH series are not not habit-forming and the desire to use them can actually decrease with use. They are thought to be mostly self-regulating.

Tolerance to the effects of 25x-NBOH is built almost immediately after ingestion. After that, it takes about 1 week for the tolerance to be reduced to half and 2 weeks to be back at baseline (in the absence of further consumption). 25x-NBOH presents cross-tolerance with all psychedelics, meaning that after the consumption of 25I-NBOMe all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Serotonin syndrome risk

Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • United Kingdom - The majority of synthesised 25x-NBOH substances are Class A drugs in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause.[3] Any compounds not covered by the clause are illegal to produce, supply, or import under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[4]

See also


  1. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., Abdollahi, M. (June 2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. ISSN 1556-9039. 
  2. Gillman, P. K. (2005). "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity". British Journal of Anaesthesia. 95 (4): 434–441. doi:10.1093/bja/aei210 . eISSN 1471-6771. ISSN 0007-0912. OCLC 01537271. PMID 16051647. 
  3. The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014 
  4. Psychoactive Substances Act 2016