2C-x

All derivatives of 2,5-dimethoxyphenethylamine have a phenethylamine backbone with two methoxy groups in positions 2 and 5 of the aromatic ring and they further contain different lipophilic substituents in position 4.

The phenethylamine backbone consists of a phenyl ring joined to an amine group through an ethyl chain. All compounds in the 2C-x series consist of this as their core structure.

Note: This list does not include 2C-T-x, 25x-NBOH, 25x-NBOMe, DOx.

Classic 2C-x compounds

Other compounds, derivated from 2,5-dimethoxyphenethylamine

The 2C-x chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective serotonin reuptake inhibitor) or tricyclic antidepressants in general to avoid serotonin syndrome, a potentially life-threatening condition in which an abundance of serotonin is built up the body, causing many physical and cognitive health problems.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• 5-meo-xxt - The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
• amphetamines - The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
• cannabis Cannabis has a strong, volatile synergy with psychedelics. While often used to intensify or prolong their effects, the combination increases the risk of adverse psychological effects like anxiety, paranoia, panic attacks, and psychosis. Anecdotal reports often describe cannabis use as the triggering event for a bad trip or psychosis. Caution is advised.
• cocaine - The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
• maois - MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably"]

nbomes NBOMes and NBOHs can both cause vasoconstriction and stimulation. The combination is generally unnecessary because of the stimulating effects of psychedelics (the 2C-x series in particular.) Combination of the stimulating effects may be uncomfortable.

• tramadol - Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.
• amt

• Austria: The 2C-x family is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich) or the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).^{[citation needed]}
• USA: In the US, most of the 2C-x chemicals are Schedule I under the American Food and Drug Administration Safety and Innovation Act of 2012 and the Federal Analogue Act.^[1]
• Australia: Australia has a blanket ban over all substituted phenethylamines including the entire 2C-X family.^[2]
• Switzerland: Most 2C-x drugs are illegal to possess, produce and sell.^[3]
• Canada: All 2C-x phenethylamines are schedule III in Canada. ^[4]
• United Kingdom: Most of the 2C-x chemical class are Class A drugs in the United Kingdom as a result of the phenethylamine catch-all clause.^[5]
• Germany: Most 2C-x compounds are controlled under BtMG Anlage I, making them illegal to manufacture, import, possess, sell, or transfer them without a license.^[6] Other 2C-x compounds are controlled by the NpSG, as they are derivatives of 2-Phenethylamine. Production, and sale is illegal. Possession and import, although illegal, is not penalized if intended for self-consumption.^[7]

• Responsible use
• DOx
• 2C-T-x
• 25x-NBOMe
• Psychedelics
• Phenethylamines

• 2C (Wikipedia)

• Dean, B. V., Stellpflug, S. J., Burnett, A. M., & Engebretsen, K. M. (2013). 2C or not 2C: Phenethylamine Designer Drug Review. Journal of Medical Toxicology, 9(2), 172-178. https://doi.org/10.1007/s13181-013-0295-x