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| Summary sheet: Amisulpride |
| Amisulpride | |||||||||||||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||||||||||||
| Common names | Amisulpride, Solian, Barhemsys | ||||||||||||||||||||||||||||||||
| Systematic name | 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide | ||||||||||||||||||||||||||||||||
| Class Membership | |||||||||||||||||||||||||||||||||
| Psychoactive class | Antipsychotic | ||||||||||||||||||||||||||||||||
| Chemical class | Benzamide | ||||||||||||||||||||||||||||||||
| Routes of Administration | |||||||||||||||||||||||||||||||||
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Amisulpride (also known under brand names including Solian and Barhemsys) is a atypical antipsychotic substance of the benzamide class.
History and culture
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This History and culture section is a stub. As a result, it may contain incomplete or wrong information. You can help by expanding it. |
Chemistry
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This chemistry section is incomplete. You can help by adding to it. |
Amisulpride is the 4-position amino substitution of sulpiride which in turn is based on a benzamide core.
Pharmacology
Amisulpride primarily works by antagonising D2 and D3 dopamine receptors aswell as the 5-HT7, 5-HT2A and 5-HT2B serotonin receptors.
It is also known to act as a GHB receptor agonist and Mu- Delta- Kappa-opioid agonist[1]
Subjective effects
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This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it. |
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects 
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- Sedation
- Increased salivation
- Headaches
- Nausea
- Vomiting
- Dry mouth anti-cholinergic effect
- Constipation anti-cholinergic effect
- Increased prolactin potentially causing the absence of the menstrual cycle, breast enlargement, breast milk secretion not related to breastfeeding, impaired fertility, impotence, breast pain, etc
Cognitive effects 
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- Thought deceleration
- Thought acceleration contradictory side effect
- Dream potentiation
Experience reports
There are currently 0 experience reports which describe the effects of this substance in our experience index.
Additional experience reports can be found here:
Toxicity and harm potential
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This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. |
It is strongly recommended that one use harm reduction practices when using this substance.
Lethal dosage
Tolerance and addiction potential
Dangerous interactions
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This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it. |
Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Legal status
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This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
- Australia: Amisulpride is a Schedule 4 prescription only drug.[citation needed]
- Brazil: Amisulpride is a Class C1 prescription only drug.[2]
- United Kingdom: Amisulpride is a prescription only drug.[3]
- United States: Amisulpride is a prescription only drug.[citation needed]
See also
External links
References
- ↑ Rehni AK, Singh TG, Chand P: Amisulpride-induced seizurogenic effect: a potential role of opioid receptor-linked transduction systems. Basic Clin Pharmacol Toxicol. 2011 May;108(5):310-7. doi: 10.1111/j.1742-7843.2010.00655.x. Epub 2010 Dec 22. (PubMed ID 21176108)
- ↑ https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992
- ↑ https://web.archive.org/web/20200226225750/https://www.medicines.org.uk/emc/product/2726/smpc