Talk:Etomidate
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| Summary sheet: Etomidate |
Etomidate (USAN, INN, BAN; marketed as Amidate) is a short-acting intravenous anaesthetic agent used for the induction of general anaesthesia and sedation for short procedures such as reduction of dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy. It was developed at Janssen Pharmaceutica in 1964 and was introduced as an intravenous agent in 1972 in Europe and in 1983 in the United States.
The most common side effects include venous pain on injection and skeletal muscle movements.
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| Chemical Nomenclature | |||||||||||||||||||||||||||||||
| Common names | 2-MMC, Ortomephedrone | ||||||||||||||||||||||||||||||
| Substitutive name | 2-Methylmethcathinone | ||||||||||||||||||||||||||||||
| Systematic name | 2-(methylamino)-1-(2-methylphenyl)propan-1-one | ||||||||||||||||||||||||||||||
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| Psychoactive class | Depressants | ||||||||||||||||||||||||||||||
| Chemical class | Cathinone | ||||||||||||||||||||||||||||||
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History and culture
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This History and culture section is a stub. As a result, it may contain incomplete or wrong information. You can help by expanding it. |
Chemistry
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This chemistry section is incomplete. You can help by adding to it. |
Pharmacology
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This pharmacology section is incomplete. You can help by adding to it. |
Etomidate is an imidazole-derived, non-barbiturate, short-acting intravenous anesthetic. The etomidate distribution model conforms to the three-compartment drug distribution model, and the distribution volume is 2.2-4.5L/kg. Because of its high binding capacity to serum proteins and rapid drug metabolism, the time-dose-related half-life does not extend significantly with continuous infusion. It is not only suitable for single administration during induction, but also for intraoperative maintenance. The site of action of intravenous anesthetics is generally related to gamma-aminobutyric acid, and the important target of etomidate's molecular mechanism of action is the GABA-A receptor.
Forman found in experimental studies that different concentrations of etomidate act on GABA-A receptors in different ways. Commonly used doses of etomidate are similar to GABA-A receptor agonists, prolonging the decay time of postsynaptic inhibitory currents, lengthening the duration of inhibition, and also activating extrasynaptic GABA receptors. Excessive doses of etomidate act directly on GABA-A receptors and are similar to GABA allosteric activators. Studies have found that etomidate not only acts on GABA receptors, but also on α-2β adrenergic receptors, thereby causing vasoconstriction and maintaining hemodynamic stability.[1]
Subjective effects
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This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it. |
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects 
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Visual effects 
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Enhancements
Distortions
Geometry
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Hallucinatory states
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Cognitive effects 
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- Irritability Excessive use of etomidate can cause irritability
- Cognitive effect2
- Cognitive effect3
Auditory effects 
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Multi-sensory effects 
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Transpersonal effects 
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Experience reports
There are currently 0 experience reports which describe the effects of this substance in our experience index.
Additional experience reports can be found here:
Toxicity and harm potential
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This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. |
It is strongly recommended that one use harm reduction practices when using this substance.
Lethal dosage
Tolerance and addiction potential
Dangerous interactions
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This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it. |
Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Legal status
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This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
See also
External links
(List along order below)
- SUBSTANCE (Wikipedia)
- SUBSTANCE (Erowid Vault)
- SUBSTANCE ([PiHKAL or TiHKAL] / Isomer Design)
Literature
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References
- ↑ 依托咪酯持续输注在临床中的应用, additional text.
- ↑ Abuse etomidate can be motor control loss, 禁毒宣传：滥用右美沙芬者的状态