Category:Panels - PsychonautWiki

Category:Panels

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This guide is provided for informational and educational purposes only. We do not encourage you to break the law and cannot claim any responsibility for your actions.

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Warnings

intense trips {{Warning/Short-acting intense trips}}

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A trip sitter is recommended with this substance that often is smoked in heavy doses. Short-acting intense trips may cause mental and physical side effects days after the hit has been taken.

The overwhelming effects often require post-processing. It may take 2 days before physical side effects become noticeable, like shift in hearing. Using additional substances without a break (2 days + a few days to recover if you notice any side effects) increases the risk to get a bad post-trip.

{{Warning/Alcohol}}

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Alcohol is among the most used drugs

"There is no safe amount that does not affect health" (World Health Organization 2023).[1] Also, the WHO organization International Agency for Research on Cancer (IARC) lists ethanol as a Group 1 carcinogen in humans.[2] Alcohol is the most harmful drug overall, and the only drug more harmful to others than to users (2010 DrugScience study).[3] The therapeutic index for ethanol is only 10%.[4] In the US, alcohol is subject to the FDA drug labeling Pregnancy Category X (Contraindicated in pregnancy: Studies in animals or humans have demonstrated fetal abnormalities...); Alcohol is a teratogen and may cause fetal alcohol spectrum disorders (FASDs).

{{Warning/Alcohol induced dose dumping (AIDD)}}

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Alcohol may be dangerous to combine with modified-release dosage medications.

This dose dumping effect is an unintended rapid release of large amounts of a given drug, when administered through a modified-release dosage while co-ingesting ethanol.[5] This is considered a pharmaceutical disadvantage due to the high risk of causing drug-induced toxicity by increasing the absorption and serum concentration above the therapeutic window of the drug. The best way to prevent this interaction is by avoiding the co-ingestion of both substances or using specific controlled-release formulations that are resistant to AIDD.


{{Warning/2C-P}}

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2C-P is very difficult to dose properly.

Due to its unusually slow onset, long duration, and steep dose-response curve, it is strongly discouraged to re-dose 2C-P earlier than every 3 hours to a total of 2 milligrams above a previously evaluated dose. Also, even for experienced trippers, it is advised to not go above a common dose for the first time (see dosage table) per 70 kg body weight, as the session will last for several times longer compared to most psychedelics. Please see this section for more details.

{{Warning/2C-T-7}}

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Serious injury or death may occur if 2C-T-7 is insufflated or combined with certain substances and medications (e.g. MAOIs or RIMAs)[6][7][8]

It is strongly discouraged to insufflate (snort), eyeball, administer non-orally, or combine this substance with certain other substances. Please see this section for more details.

{{Warning/3-HO-PCE}}

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The toxicity and risks of 3-HO-PCE are as of this time totally unknown and there is evidence to suggest that it may be significantly more dangerous to use than any previous member of the arylcyclohexylamine class.

It should be noted that this substance has been speculated to come with the unique risk of fatal respiratory overdose due to its combination of potent opioid and dissociative effects. Until more is learned about this substance, users are advised to approach this substance with extreme caution, if not avoid it entirely, due to the unpredictable dangers that may come with its use.

{{Warning/3-MeO-PCE}}

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3-MeO-PCE may have a higher risk of causing mania, delusions, and psychosis than other dissociatives.

It is strongly discouraged to take this substance in high dosages, for multiple days in a row, or in combination with other substances known to increase the risk of psychosis. Please see this section for more details.

{{Warning/3-MeO-PCP}}

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3-MeO-PCP may be more likely to cause mania, delusions, and psychosis than other dissociatives.[9][10][11]

It is strongly discouraged to take this substance in high dosages, for multiple days in a row, or in combination with other substances that increase the risk of psychosis. Please see this section for more details.

{{Warning/5-MeO-DMT}}

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WARNING: 5-MeO-DMT is not a valid substitute for DMT.

Despite what their names might suggest, 5-MeO-DMT and DMT have distinct effects and risk profiles and should be regarded as completely separate entities. Please see this this section for more information.

{{Warning/Acetylfentanyl}}

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Death may occur when Acetylfentanyl is combined with depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, thienodiazepines or other GABAergic substances.[12]

It is strongly discouraged to combine either heavy or moderate dosages of these substances together.

{{Warning/Amanita muscaria}}

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It is important to heat fly agaric before consumption.

Please read Fly agaric: Ibotenic acid decarboxylation to muscimol to learn how to convert the relatively neurotoxic compound (speculated to be a stimulant[13][14]) ibotenic acid to muscimol.

Also, novel edibles "Amanita Mushroom Gummies" contain a substantial amount of ibotenic acid along with muscimol and muscarine. Given the toxicity of ibotenic acid, the consumption of those preparations even in small doses should be avoided![15]

{{Warning/Barbiturates}}

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Death may occur when barbiturates are combined with depressants such as opiates, benzodiazepines, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[12]

It is strongly discouraged to consume moderate to heavy dosages of these substances together.

{{Warning/Belladonna}}

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Belladonna is known to cause dangerous and extremely unpleasant experiences.

Please use responsible use practices when trying this drug and always have a trip sitter.

{{Warning/BHO}}

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Do not perform this procedure indoors.

Due to the explosive nature of the solvents involved, attempting this procedure in underventilated areas (e.g. such as a small apartment room or basement) can result in serious injury, death or the destruction of property.

{{Warning/Black tar heroin}}

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Black tar heroin is dangerous to inject

It's not practical to make black tar heroin sterile, for example, by heating a solution with a lighter for a minute. Black tar heroin injection is associated with Clostridium botulinum infection. Prion: "For prion elimination, various recommendations state 121–132 °C (250–270 °F) for 60 minutes or 134 °C (273 °F) for at least 18 minutes."[16] A pressure cooker reach 120 °C at full pressure. However, we don't recommend black tar heroin injection even if you own a pressure cooker with a PSI meter due to lack of safety data.

{{Warning/Cannabis}}

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Cannabis is common, and its tolerance is moderate, so intoxication can occur frequently. Frequent use of cannabis with more than 10% THC increased the risk of developing a psychotic disorder. 5% THC provides pain relief as well as intoxication.[17] We recommend you to dilute your cannabis product (see below).

Analysis of data from 901 patients showed that the use of high-potency cannabis (THC content ≥10%) was associated with a modestly increased risk of developing a psychotic disorder compared to never using cannabis.[18]

Street cannabis has an average THC content of 12%,[19] and medical cannabis products have more than 10% THC.[17] We recommend you to weigh and dilute cannabis buds, and hashish, with 3 times more, and 10 times more hemp respectively. Avoid mixing with tobacco to avoid nicotine: Stimulants should be used with caution in combination with [quasi-]psychedelics including cannabis.

{{Warning/Cocoa strains}}

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Cocoa is yummy! However, some cocoa strains have high caffeine content, and stimulants combined with psychedelics should be used with caution.

The Forastero strain contains virtually no caffeine, while the Criollo contains a lot of caffeine.

To make chocolate, it's safer to mix cocoa solids with specified strain and white chocolate, or just using white chocolate, rather than using baking chocolate without any strain declared in the ingredients.

{{Warning/Desoxypipradrol}}

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Desoxypipradrol may lead to states of psychosis, mania and addiction at a significantly higher rate than other stimulants.

Due to its unusually long half-life and extreme potency, it is strongly discouraged to abuse this substance in high doses, multiple days in a row, or in combination with other substances known to increase the risk of psychosis. Please see this section for more details.

{{Warning/Ephylone}}

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Ephylone has been linked to numerous overdoses and deaths.

It is strongly discouraged to use this substance in high doses, multiple times in a row, or in combination with other substances known to increase the risk of psychosis or serotonin syndrome. Please see this section for more details.

{{Warning/Fentanyl}}

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This substance is extraordinarily potent (i.e. active in the microgram range). For this reason, it should be handled with extreme care and never be eyeballed. Fentanyl can also be fatal when combined with depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, thienodiazepines or other GABAergic substances.[12]

It is strongly encouraged to wear gloves while handling, use volumetric dosing combined with a milligram scale, and to not consume either moderate or heavy dosages of other depressants in combination with this drug.

{{Warning/Hyoscyamus niger}}

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Hyoscyamus niger is known to cause dangerous and extremely unpleasant experiences.

Please use responsible use practices when trying this drug and always have a trip sitter.

{{Warning/Ibogaine}}

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Ibogaine can cause life-threatening heart complications.[20]

It is strongly discouraged to use this substance in high doses or for multiple days in a row. Additionally, a trip sitter with proper medical training and equipment must be present. Please see this section for more details.

{{Warning/MAOI}}

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Always check if your MAOIs also inhibit other substances. Most MAOIs are also cytochrome P450 inhibitors and some are also acetylcholinesterase inhibitors (AChEIs)

Substances that inhibits the cytochrome P450 system’s ability to metabolize certain drugs, leading to an overall increase in processing times.

{{Warning/Mandrake}}

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Mandrakes are very poisonous and known to cause dangerous and extremely unpleasant experiences.

Please use responsible use practices when trying this drug and always have a trip sitter.

{{Warning/MDMA-Pills}}

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Do not trust underground brand names, they are easily falsified

The previously good reputation of 'Mistubishi's' amongst ecstasy-users has been dealt a blow with the discovery of deadly batches (PMA has been found in White Mitsubishi,[21] PMMA has been found in Red Mitsubishi[22])

{{Warning/MDPV}}

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MDPV may cause psychosis, mania and addiction at a significantly higher rate than other stimulants.

Due to its unusually long duration, extreme potency, and compulsive nature, it is strongly discouraged to abuse this substance in high doses, multiple days in a row, or in combination with other drugs known to increase the risk of psychosis. Please see this section for more details.

{{Warning/Mushroom hunting}}

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Hunting psychoactive mushrooms in nature can be very dangerous.

Caution is advised because poisonous or deadly mushrooms can easily be mistaken for edible ones.

{{Warning/Morning glory}}

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Commercial seeds are often treated with fungicides

It is important to note that each seed is treated with fungicides and other toxic substances, which can further exacerbate the toxicity levels.[23]

{{Warning/Nitrous oxide}}

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Nitrous oxide can cause irreversible neurotoxic damages

Frequent and/or chronic use can cause vitamin B12 depletion, such as other rapidly vitamin B12 depleting substance, may lead to severe nerve damage.[24] We recommend that you always supplement with vitmamin B12 if you use this substance, regardless dose and frequency to be on the safe side. Especially those with "decreased vitamin B12 absorption, such as in those with small bowel resection, irritable bowel disease, and/or pernicious anemia, and those with reduced intake, such as in vegans and vegetarians".[25] Additionally, improper use puts the user at risk of oxygen deprivation. It is highly advised to use harm reduction practices if using this substance.

{{Warning/Nitrous oxide - Containers}}

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Please recycle empty whipped cream containers.

Whipped-cream chargers dumped in nature.

{{Warning/PCE}}

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PCE may cause psychosis and mania at a significantly higher rate than other dissociatives.[26][27]

It is strongly discouraged to use this substance in high doses or multiple days in a row. Please see this section for more details.

{{Warning/PCP}}

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PCP may cause psychosis and mania at a significantly higher rate than other dissociatives.[28][29]

It is strongly discouraged to use this substance in high doses or multiple days in a row. Please see this section for more details.

{{Warning/PhenibutOD}}

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Death may potentially occur when phenibut is combined with depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, thienodiazepines or other GABAergic substances.[12]

It is strongly discouraged to consume moderate to heavy dosages of these substances together.

{{Warning/PMA}}

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PMA can cause life-threatening side effects (such as hyperthermia and serotonin syndrome) even at moderate doses.

As a result, using this substance is strongly discouraged. It is also advised to always test your MDMA for the presence of PMA using a reagent testing kit as it is a common adulterant. Please see this section for more details.

{{Warning/PMMA}}

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PMMA can cause serious side effects even at moderate doses, such as hyperthermia and serotonin syndrome, which can easily result in death or hospitalization.

As a result, it is strongly discouraged to use this substance. Please see this section for more details.

{{Warning/Sufentanil}}

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Sufentanil is extraordinarily potent (i.e. active in the micrograms), to the point that the pure powder can result in a fatal overdose if spilled on one's skin. For this reason, it should never be eyeballed.

Sufentanil can also be fatal when combined with depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, thienodiazepines or other GABAergic substances.[12]

It is strongly encouraged to wear gloves while handling, use volumetric dosing combined with a milligram scale, and to not consume either moderate or heavy dosages of other depressants in combination with this drug.

{{Warning/Tizanidine}}

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Tizanidine can induce dangerously low blood pressures when used in excessive doses [30] [31]

Care should be taken when taking high doses of tizanidine, even with an established tolerance. Users taking hallucinogenic doses should have a hypertensive agent available[32] or a supervisor present. Exercise extreme caution when attempting hallucinogenic doses.

{{Warning2/PeyoteHarvesting}}

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Please avoid harvesting peyote in its natural habitat.

Peyote populations are rapidly declining in nature due to over-harvesting by non-indigenous peoples. As a result, it is currently a threatened species.[33][34] Those who wish to consume peyote are encouraged to grow their own or use alternative mescaline-containing cactus species such as San Pedro or Peruvian Torch.

Information

{{Information/Antipsychotic}}

{{Information/Cannabis butter}}

{{Information/MAOIs and RIMAs}}

{{Information/Near-death experience}}

{{Information/Psilocybin mushroom lemon tek}}

{{Information/Substituted phenethylamines}}

{{Information/THC production}}

{{Information/Tyrosine}}

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  1. ↑ https://www.who.int/europe/news/item/04-01-2023-no-level-of-alcohol-consumption-is-safe-for-our-health.  Missing or empty |title= (help)
  2. ↑ Agents Classified by the IARC Monographs, Volumes 1–111 Template:Webarchive. monographs.iarc.fr
  3. ↑ Nutt DJ, King LA, Phillips LD (November 2010). "Drug harms in the UK: a multicriteria decision analysis". Lancet. 376 (9752): 1558–65. CiteSeerX 10.1.1.690.1283 Freely accessible. doi:10.1016/S0140-6736(10)61462-6. PMID 21036393.  Unknown parameter |s2cid= ignored (help)
  4. ↑ Gable RS (June 2004). "Comparison of acute lethal toxicity of commonly abused psychoactive substances" (PDF). Addiction. 99 (6): 686–96. doi:10.1111/j.1360-0443.2004.00744.x. PMID 15139867. 
  5. ↑ D'Souza S, Mayock S, Salt A (December 2017). "A review of in vivo and in vitro aspects of alcohol-induced dose dumping". AAPS Open (in English). 3 (1). doi:10.1186/s41120-017-0014-9 Freely accessible. ISSN 2364-9534. 
  6. ↑ "Third Confirmed 2C-T-7 Death". Erowid. April 10, 2001. 
  7. ↑ "A Reported 2C-T-7 Death". Erowid. July 2003. 
  8. ↑ "Second Reported 2C-T-7 Death". Erowid. April 2, 2001. 
  9. ↑ The Big & Dandy 3-MeO-PCP Thread - Part 2 (Bluelight) | http://www.bluelight.org/vb/threads/697059-The-Big-amp-Dandy-3-MeO-PCP-Thread-Part-2
  10. ↑ The Big & Dandy 3-MeO-PCP Thread - Mad Manic Meo 3nity | http://www.bluelight.org/vb/threads/760934-The-Big-amp-Dandy-3-MeO-PCP-Thread-Mad-Manic-Meo-3nity
  11. ↑ The Big & Dandy 3-MeO-PCP Thread - Part 1 (Bluelight) | http://www.bluelight.org/vb/threads/454099-The-Big-amp-Dandy-3-MeO-PCP-Thread-%28Part-1%29
  12. ↑ 12.0 12.1 12.2 12.3 12.4 Risks of Combining Depressants - TripSit  Cite error: Invalid <ref> tag; name "tripsit" defined multiple times with different content Cite error: Invalid <ref> tag; name "tripsit" defined multiple times with different content
  13. ↑ Chilton 1975; Theobald et al. 1968
  14. ↑ Chilton 1975; Ott 1976a
  15. ↑ https://www.kykeonanalytics.com/news/New-trend-of-Amanita-Mushroom-Gummies-potentially-neurotoxic-edibles/
  16. ↑ Rutala, WA; Weber, DJ; Society for Healthcare Epidemiology of, America (February 2010). "Guideline for disinfection and sterilization of prion-contaminated medical instruments". Infection control and hospital epidemiology. 31 (2): 107–17. doi:10.1086/650197. PMID 20055640. 
  17. ↑ 17.0 17.1 https://www.europeanpharmaceuticalreview.com/news/115909/over-90-percent-of-medical-marijuana-in-us-contains-high-levels-of-thc-study-finds/
  18. ↑ https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(19)30048-3/fulltext
  19. ↑ https://pubmed.ncbi.nlm.nih.gov/33508497/
  20. ↑ Koenig, X.; Hilber, K. (2015). "The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation". Molecules. 20 (2): 2208–2228. doi:10.3390/molecules20022208. ISSN 1420-3049. OCLC 641147188. PMC 4382526 Freely accessible. PMID 25642835. 
  21. ↑ Shulgin Index, p811
  22. ↑ http://www.ecstasy.org/testing/pma.html
  23. ↑ https://ejfs.springeropen.com/articles/10.1186/s41935-017-0016-8
  24. ↑ Flippo, T. S. (1 December 1993). "Neurologic Degeneration Associated With Nitrous Oxide Anesthesia in Patients With Vitamin B12 Deficiency". Archives of Surgery. 128 (12): 1391. doi:10.1001/archsurg.1993.01420240099018. ISSN 0004-0010. 
  25. ↑ Campdesuner, V; Teklie, Y; Alkayali, T; Pierce, D; George, J (9 July 2020). "Nitrous Oxide-Induced Vitamin B12 Deficiency Resulting in Myelopathy". Cureus. 12 (7): e9088. doi:10.7759/cureus.9088. PMC 7366039 Freely accessible. PMID 32685323. 
  26. ↑ Luisada, P. V. M. D. (1978), The Phencyclidine Psychosis: Phenomenology and Treatment." Phencyclidine (PCP) Abuse: An Appraisal., National Institute on Drug Abuse 
  27. ↑ Tasman, A., Kay, J., Lieberman, J. A., First, M. B., Riba, M. (5 February 2015). Psychiatry. John Wiley & Sons. ISBN 9781118753361. 
  28. ↑ Luisada, P. V., M. D. (1978), “The Phencyclidine Psychosis: Phenomenology and Treatment.” Phencyclidine (PCP) Abuse: An Appraisal., National Institute on Drug Abuse 
  29. ↑ Tasman, A., Kay, J., Lieberman, J. A., First, M. B., Riba, M. (5 February 2015). Psychiatry. John Wiley & Sons. ISBN 9781118753361. 
  30. ↑ Johnson TR, Tobias JD. Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension. J Child Neurol. 2000 Dec;15(12):818-9. doi: 10.1177/088307380001501211. PMID: 11198499.
  31. ↑ Chaugai S, Dickson AL, Shuey MM, Feng Q, Barker KA, Wei WQ, Luther JM, Stein CM, Chung CP. Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study. Clin Pharmacol Ther. 2019 Mar;105(3):703-709. doi: 10.1002/cpt.1233. Epub 2018 Oct 18. PMID: 30223305; PMCID: PMC6379114.
  32. ↑ Sharma S, Hashmi MF, Bhattacharya PT. Hypotension. [Updated 2022 Feb 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.
  33. ↑ Martin Terry (Sul Rose State Univ., A. (19 November 2009). "IUCN Red List of Threatened Species: Lophophora williamsii". IUCN Red List of Threatened Species. 
  34. ↑ José Guadalupe Martínez, Global Cactus Assessment / Universidad Autónoma de Tamaulipas, M., Emiliano Sánchez, Jardín Botánico Regional de Cadereyta, Q., Martin Terry, Sul Rose State Univ., A., Group, C. G.-H., IUCN S. C. & S. P. S. (18 November 2009). "IUCN Red List of Threatened Species: Lophophora diffusa". IUCN Red List of Threatened Species. 
  35. ↑ Garcia, Eddie; Santos, Cynthia (2022). "Monoamine Oxidase Inhibitor Toxicity". StatPearls. StatPearls Publishing. 
  36. ↑ "2C-I-NBOMe (25I) Effects". Erowid. 

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