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| Summary sheet: Salbutamol |
| Salbutamol | |||||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||||
| Common names | Salbutamol, Albuterol, Ventolin | ||||||||||||||||||||||||
| Systematic name | (RS)-4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol | ||||||||||||||||||||||||
| Class Membership | |||||||||||||||||||||||||
| Psychoactive class | Stimulant | ||||||||||||||||||||||||
| Chemical class | Phenethylamine | ||||||||||||||||||||||||
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Salbutamol (also known as Albuterol, or by brand names including Ventolin) is a stimulant substance of the phenethylamine class, acting as a β₂ adrenergic receptor agonist. It is commonly used for the treatment of asthma and COPD(chronic obstructive pulmonary disease).
History and culture
Salbutamol was discovered 1966, by a Team lead by David Jack, the first medication laucned was Ventolin. Until today Salbutamol remains one of the most effective rescue inhalers [citation needed].[1] Salbutamol has a history of being used for doping due to its bronchodialating effects.[2]
Chemistry
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This chemistry section is incomplete. You can help by adding to it. |
Salbutamol is sold as a racemic mixture. The (R)-(−)-enantiomer (CIP nomenclature) is shown in the image at right (top), and is responsible for the pharmacologic activity; the (S)-(+)-enantiomer (bottom) blocks metabolic pathways associated with elimination of itself and of the pharmacologically active enantiomer (R)[3]
Pharmacology
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This pharmacology section is incomplete. You can help by adding to it. |
Salbutamol acts on β2-adrenergic receptors inducing muscle relaxation.[4]
Parmacokinetics
Inhaled Salbutamol affects bronchial muscles without entering the bloodstream. Trace amounts appear two to three hours after inhalation. Within 24h approximately 70% of the administered dose is eliminated.[4]
Subjective effects
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This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it. |
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Cognitive effects 
Experience reports
There are currently 0 experience reports which describe the effects of this substance in our experience index.
Additional experience reports can be found here:
Toxicity and harm potential
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This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. |
Warning: Overdose can result in lactic acidosis, arrhythmias, tremors, hypoglykemia or hyperglykemia.[4] It is strongly recommended that one use harm reduction practices when using this substance.
Lethal dosage
The LD50 in mice is relatively high with > 2500 mg per kg.[5]
Tolerance and addiction potential
Salbutamol as physical dependence and addiction potential. Safe usage is about twice a week.[6]
Dangerous interactions
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This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it. |
Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
- MAOIs Increased risk of adverse cardiovescular events
- Beta-blockers neutralize effects
- wikipedia:Diuretics May worsen ECG changes and hypoglykemia
- Digoxin
Legal status
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This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
See also
External links
References
- ↑ "Sir David Jack, who has died aged 87, was the scientific brain behind the rise of the pharmaceuticals company Glaxo". The Telegraph. 17 November 2011. Archived from the original on 25 November 2011.
- ↑ Fitch, Ken D. (2017). "The enigma of inhaled salbutamol and sport: unresolved after 45 years". Drug Testing and Analysis. 9 (7): 977–982. doi:10.1002/dta.2184. ISSN 1942-7603.
- ↑ Metha, Akul (2011-01-27). "Adrenergics and Cholinergic their Biosynthesis, Metabolism and Structure Activity Relationships". PharmaXChange.info. Retrieved 2024-03-12.
- ↑ 4.0 4.1 4.2 Johnson, Donavon B.; Merrell, Brigham J.; Bounds, Connor G. (2024-01-10). "Albuterol". StatPearls Publishing. PMID 29489143. Retrieved 2024-03-12.
- ↑ "MATERIAL SAFETY DATA SHEET" (PDF). Pfizer Ltd. Retrieved 2024-03-12.
- ↑ "Patient safety spotlight: the risks of overprescribing Salbutamol inhalers for asthma". General Pharmaceutical Council. 2022-05-31. Retrieved 2024-03-12.
- ↑ Johnson, Donavon B.; Merrell, Brigham J.; Bounds, Connor G. (2024-01-10). "Albuterol". StatPearls Publishing. PMID 29489143. Retrieved 2024-03-12.