Wakefulness is defined as an increased ability to stay conscious without feeling sleepy combined with a decreased need to sleep. It is contrasted with stimulation in that it does not directly increase one's energy levels above a normal baseline but instead produces feelings of a wakeful, well-rested, and alert state. If one is sleepy before using this substance, the impulse to sleep will fade, keeping one’s eyes open will become easier, and the cognitive fog of exhaustion will be reduced. However, sufficiently accumulated sleep deficiency can overpower or negate this effect in extreme cases.
Wakefulness is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as stimulants, nootropics, and psychedelics. However, it is worth noting that the few compounds which selectively induce this effect without a number of other accompanying effects are referred to as eugeroics or wakefulness-promoting agents. These include modafinil and armodafinil.
Anecdotal reports which describe this effect within our experience index include:
- Experience: 15mg 2C-B (oral) - A pleasant low-dose evening with Nexus
- Experience:1000 Morning Glory seeds - Rediscovering the Self
- Experience:120mg - Garden of The Gods
- Experience:1g Methiopropamine - Chasing the Chalky Dragon
- Experience:25mg - A labyrinth of organs and a storybook walk
- Experience:300µg LSD - Togetherness and the Silent Dusk
- Experience:30mg - Psychostimulant egodeath
- Experience:30mg Isopropylphenidate - IPPH As A Study Aid
- Experience:37mg Isopropylphenidate - Getting Shit Done With Isopropylphenidate
- Experience:75mg 3-FMA - Perfect Blend of Euphoria and Functionality
- Experience:800 seeds LSA - My First Trip Ever
- Experience:BK-2C-B - Various experiences
- Experience:LSA (20 HWBR seeds) – A pleasant adventure with a harsh body load
- Experience:Marijuana Withdrawal
- Experience:Mushrooms and Snuff Films -- Trip Report (3.5 grams)
- Experience:Zopiclone hppd?
- Porkka-Heiskanen, T. (1997). "Adenosine: A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness". Science. 276 (5316): 1265–1268. doi:10.1126/science.276.5316.1265. ISSN 0036-8075.
- Repantis, Dimitris; Schlattmann, Peter; Laisney, Oona; Heuser, Isabella (2010). "Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review". Pharmacological Research. 62 (3): 187–206. doi:10.1016/j.phrs.2010.04.002. ISSN 1043-6618.
- Engber, T.M; Dennis, S.A; Jones, B.E; Miller, M.S; Contreras, P.C (1998). "Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: comparison with amphetamine". Neuroscience. 87 (4): 905–911. doi:10.1016/S0306-4522(98)00015-3. ISSN 0306-4522.
- Caldwell, John A.; Caldwell, J. Lyn; Smyth, Nicholas K.; Hall, Kecia K. (2000). "A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study". Psychopharmacology. 150 (3): 272–282. doi:10.1007/s002130000450. ISSN 0033-3158.
- Myrick, Hugh; Malcolm, Robert; Taylor, Brent; LaROWE, STEVEN (2004). "Modafinil: Preclinical, Clinical, and Post-Marketing Surveillance—A Review of Abuse Liability Issues". Annals of Clinical Psychiatry. 16 (2): 101–109. doi:10.1080/10401230490453743. ISSN 1040-1237.
- Scammell, Thomas E.; Estabrooke, Ivy V.; McCarthy, Marie T.; Chemelli, Richard M.; Yanagisawa, Masashi; Miller, Matthew S.; Saper, Clifford B. (2000). "Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness". The Journal of Neuroscience. 20 (22): 8620–8628. doi:10.1523/JNEUROSCI.20-22-08620.2000. ISSN 0270-6474.