3C-E - PsychonautWiki
Summary sheet: 3C-E
Chemical Nomenclature
Common names 3C-E, 3C-Escaline
Substitutive name 3,5-Dimethoxy-4-ethoxyamphetamine
Systematic name 1-(4-Ethoxy-3,5-dimethoxyphenyl)propan-2-amine
Class Membership
Psychoactive class Psychedelic
Chemical class Amphetamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 20 mg
Light 30 - 40 mg
Common 40 - 60 mg
Strong 60 - 80 mg
Heavy 80 mg+
Total 10 - 16 hours
Onset 1 - 2 hours
Peak 4 - 8 hours
Offset 3 - 6 hours
After effects 3 - 6 hours

Threshold 15 mg
Light 20 - 35 mg
Common 35 - 60 mg
Strong 60 - 70 mg
Heavy 70 mg+
Total 5 - 12 hours
Onset 5 - 90 minutes
Peak 4 - 7 hours
Offset 2 - 5 hours
After effects 3 - 5 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


3,5-Dimethoxy-4-ethoxyamphetamine (commonly known as 3C-E or 3C-Escaline) is a synthetic psychedelic compound of the amphetamine chemical class. Although it's name suggests it may be related to the 2C-x family, this is not the case. 3C-E has the structure of escaline, a mescaline analogue, with an additional carbon rendering it a substituted amphetamine.

3C-E was presumably first synthesized by Alexander Shulgin and published in his book PiHKAL in 1991.[1]

Today, 3C-E is used for recreational and research purposes, and exclusively distributed as a gray area research chemical by online vendors. Very little is known about its effects besides its strong body high and weak visuals.


3C-E or 3,5-Dimethoxy-4-ethoxyamphetamine, is a molecule of the substituted amphetamine class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. 3C-E contains methoxy functional groups OCH3 attached to carbons R3 and R5 and an ethoxy chain OCH2CH3 attached to carbon R4 of the phenyl ring.

3C-E is the amphetamine analog of escaline.


Further information: Serotonergic psychedelic

Although its name suggests it may be related to the 2C-x family, this is not the case. 3C-E is actually the 3-Carbon analog of escaline, thus the name.

Its pharmacology can provide strong interaction with 5-HT2A receptors, which could potentially help to prevent cluster headaches or give the compound the possibility to ease the psychological suffering associated with end-stage cancer.

3C-E's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Visual effects

Cognitive effects

Multi-sensory effects

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

The toxicity and long-term health effects of recreational 3C-E use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 3C-E is a research chemical with very little history of human usage.

Anecdotal evidence from people within the community who have tried 3C-E suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

3C-E is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 3C-E is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 3C-E presents cross-tolerance with all psychedelics, meaning that after the consumption of 3C-E all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Germany: 3C-E is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.[3][4] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[5]
  • Japan: 3C-E is a controlled substance in Japan effective March 25th, 2015.[6]
  • Switzerland: 3C-E can be considered a controlled substance as a defined derivative of a-methylphenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.[7]
  • United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[8]
  • United States: 3C-E is technically not scheduled in the United States, but could be considered an analog of mescaline and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.

See also

External links



This article does not cite enough references.

You can help by adding some.

  1. Erowid Online Books : “PIHKAL” - #25 3C-E 
  2. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. ISSN 1556-9039. 
  3. "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 11, 2019. 
  4. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019. 
  5. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019. 
  6. 危険ドラッグの成分16物質を新たに指定薬物に指定 (in Japanese), 厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)], retrieved 2 May 2022 
  7. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  8. Psychoactive Substances Act 2016