3C-P

3C-P or 3,5-Dimethoxy-4-propoxyamphetamine, is a molecule of the substituted amphetamine class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH₂) group through an ethyl chain and a methyl group bound to the alpha carbon R_α. 3C-P contains methoxy functional groups OCH₃ attached to carbons R₃ and R₅ and a propoxy chain OCH₂CH₂CH₃ attached to carbon R₄ of the phenyl ring.

3C-P is the amphetamine analog of proscaline.

Although its name suggests it may be related to the 2C-x family, this is not the case. 3C-P is actually the 3-Carbon analog of proscaline, thus the name.

Its pharmacology can provide strong interaction with 5-HT2A receptors, which could potentially help to prevent cluster headaches or give the compound the possibility to ease the psychological suffering associated with end-stage cancer.

3C-P's psychedelic effects are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

According to the structure-activity-relationship between mescaline analogues, 3C-P has been identified as being more potent than mescaline and TMA-2. It has similar potency in animal studies to 3C-E, and the authors of one study on potency of mescaline analogues in rats predict that it may have similar effects and dosage to 3C-E.^[2]

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: 3C-P

The toxicity and long-term health effects of recreational 3C-P use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 3C-P is a research chemical with very little history of human usage.

Anecdotal evidence from people within the community who have tried 3C-P suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Dependence and abuse potential

3C-P is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 3C-P is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 3C-P presents cross-tolerance with all psychedelics, meaning that after the consumption of 3C-P all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
• Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 3C-P. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
• Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.^{[citation needed]}
• Tramadol - Tramadol is well-documented to lower the seizure threshold^[3] and psychedelics may act to trigger seizures in susceptible individuals.^{[citation needed]}

• United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.^[4]
• United States: 3C-P is technically not scheduled in the United States, but could be considered an analog of mescaline and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.
• Japan: 3C-P is a controlled substance in Japan effective February 28th, 2018.^[5]

• Responsible use
• Psychoactive substance index
• Mescaline
• 3C-E
• Psychedelics

• 3C-P (Wikipedia)
• 3C-P (Isomer Design)