2C-T-21

2C-T-21, or 2,5-dimethoxy-4-ethylfluorothiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH₂) group through an ethyl chain. 2C-T-21 contain methoxy functional groups CH₃O- attached to carbons R₂ and R₅ of the benzene ring as well as an ethylfluoro thioether group attached to carbon R₄ of the phenyl ring.

2C-T-21 belongs to the 2C family of phenethylamines, all of which contain methoxy groups on the 2 and 5 positions of the benzene ring.

2C-T-21's psychedelic effects are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

This compound, being similar in structure to 2C-T-2 and 2C-T-7 is also believed to potentially have MAOI properties.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: 2C-T-21

On March 9, 2004, a 22-year-old American male consumed an unknown dose of 2C-T-21 by sticking his tongue into a vial of powder he had purchased online. He developed a temperature of 108 degrees Fahrenheit (42 degrees Celsius),^[3] had a tonic-clonic seizure, and slipped into a coma before dying four days later.^{[citation needed]} These symptoms are consistent with those seen in fluoroacetate poisoning, for which there is no known effective antidote.^[5]

Fluoroacetate is hypothesized to be a metabolite of 2C-T-21.^[4] Sub-lethal doses of fluoroacetate take up to four days to clear from the body.^[6] As such, it is likely dangerous to take 2C-T-21 multiple days in a row as this poisonous metabolite will accumulate. Furthermore, sub-lethal doses may cause damage to tissue with high energy needs (e.g. the brain, gonads, heart, lungs, and fetus). This may account for the experience of a couple who became "convinced that it is toxic" in Stolaroff's book.^[2]

There is no anecdotal evidence to suggest that a single, moderate dose of 2C-T-21 can cause negative health effects, although nothing can be guaranteed.

It is strongly discouraged to administer 2C-T-21 non-orally because this may cause vomiting, numerous negative side effects, or death at high doses.

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the accurate administration of the intended dose.

Tolerance and addiction potential

2C-T-21 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-T-21 is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T-21 presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-T-21 all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

If 2C-T-21 does have MAOI effects as commonly speculated, this could indicate that 2C-T-21 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.^[7] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which releases neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:

• Austria: 2C-T-21 is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).^{[citation needed]}
• Canada: As of October 31st, 2016; 2C-T-21 is a controlled substance (Schedule III) in Canada.^[8]
• Germany: 2C-T-21 is controlled under the NpSG^[9] (New Psychoactive Substances Act) as of November 26, 2016.^[10] Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.^[11][12] The legislator considers it possible that orders of 2C-T-21 are punishable as an incitement to place it on the market.^[13]
• Switzerland: 2C-T-21 can be considered a controlled substance as a defined derivative of Phenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.^[14]
• United Kingdom: 2C-T-21 is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.^[15]
• United States: 2C-T-21 is technically not scheduled in the United States, but could be considered an analogue of 2C-T or 2C-T-7 and may therefore be considered a Schedule I drug under the Federal Analogue Act.^{[citation needed]}

• Responsible use
  • Volumetric dosing
• Research chemical
• MAOI
• 2C-x
• 2C-T-7
• 2C-E

• 2C-T-21 (Wikipedia)
• 2C-T-21 (Erowid Vault)
• 2C-T-21 (PiHKAL / Isomer Design)