2C-T-21 - PsychonautWiki
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Summary sheet: 2C-T-21
Chemical Nomenclature
Common names 2C-T-21, Aurora
Substitutive name 4-Fluoroethylthio-2,5-dimethoxyphenethylamine
Systematic name 4-(2-Fluoroethylthio)-2,5-dimethoxyphenethylamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 5 mg
Light 5 - 10 mg
Common 10 - 12 mg
Strong 12 - 15 mg
Heavy 15 mg +
Total 10 - 12 hours
Onset 90 - 120 minutes
Peak 3 - 4 hours
Offset 2 - 3 hours
After effects 2 - 4 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


2,5-Dimethoxy-4-ethylfluorothiophenethylamine (also known as 2C-T-21, or colloquially as Aurora) is a psychedelic substance of the phenethylamine chemical class that produces psychedelic effects when administered. It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule.

2C-T-21 was first synthesized by Alexander Shulgin and documented in his book PiHKAL ("Phenethylamines I Have Known and Loved"). The dosage range is listed as 8–12 mg. It is described in various reports as being generally relaxed and clear-headed with mild visual effects.[1] In his book "Thanatos To Eros, 35 Years of Psychedelic Exploration", Myron Stolaroff describes it as "not psychedelic, but a wonderful energizer", along with displaying a notable lack of appetite suppression typically observed with members of its class.[2]

In March 2004, a 22-year-old American male died after ingesting an unknown amount of 2C-T-21. This death became part of a two-year DEA investigation called "Operation Web Tryp" which ended with the arrests of 10 persons involved in the online distribution of research chemicals.[3] 2C-T-21 remains unscheduled in the United States.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-21, and it has little history of human usage. Today, it is used for the purposes of recreation and experimental psychotherapy. It has no history of being sold on the streets and is very sporadically sold online as a grey area research chemical. It is strongly advised to use harm reduction practices if using this substance.



2C-T-21, or 2,5-dimethoxy-4-ethylfluorothiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-T-21 contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring as well as an ethylfluoro thioether group attached to carbon R4 of the phenyl ring.

2C-T-21 belongs to the 2C family of phenethylamines, all of which contain methoxy groups on the 2 and 5 positions of the benzene ring.



This pharmacology section is incomplete.

You can help by adding to it.

2C-T-21's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

This compound, being similar in structure to 2C-T-2 and 2C-T-7 is also believed to potentially have MAOI properties.

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a literature which relies on collected anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death.

Physical effects

Visual effects

Cognitive effects

Auditory effects

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
We also recommend that you conduct independent research and use harm reduction practices when using this substance.

On March 9, 2004, a 22-year-old American male consumed an unknown dose of 2C-T-21 by sticking his tongue into a vial of powder he had purchased online. He developed a temperature of 108 degrees Fahrenheit (42 degrees Celsius),[4] had a tonic-clonic seizure, and slipped into a coma before dying four days later.[citation needed] Little is known about the toxicity of 2C-T-21 beyond this incident.

It is strongly discouraged to administer 2C-T-21 non-orally because this may cause vomiting, numerous negative side effects, or death at high doses.

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the accurate administration of the intended dose.

Tolerance and addiction potential

2C-T-21 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-T-21 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T-21 presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-T-21 all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.

If 2C-T-21 does have MAOI effects as commonly speculated, this could indicate that 2C-T-21 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.[5] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which releases neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Austria: 2C-T-21 is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).[citation needed]
  • Canada: As of October 31st, 2016; 2C-T-21 is a controlled substance (Schedule III) in Canada. [6]
  • Germany: 2C-T-21 is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.[7][8] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[9]
  • Switzerland: 2C-T-21 can be considered a controlled substance as a defined derivative of Phenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.[10]
  • United Kingdom: 2C-T-21 is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.[11]
  • United States: 2C-T-21 is technically not scheduled in the United States, but could be considered an analogue of 2C-T or 2C-T-7 and may therefore be considered a Schedule I drug under the Federal Analogue Act.[citation needed]

See also

External links


  1. https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=49
  2. http://www.maps.org/index.php?option=com_content&view=article&id=5406 | Thanatos to Eros
  3. https://www.dea.gov/pubs/pressrel/pr072204.html
  4. "News from DEA, News Releases, 07/22/04". 
  5. Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
  6. http://gazette.gc.ca/rp-pr/p2/2016/2016-05-04/html/sor-dors72-eng.php
  7. "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019. 
  8. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019. 
  9. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019. 
  10. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  11. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made