2C-T-21 - PsychonautWiki


Summary sheet: 2C-T-21
Chemical Nomenclature
Common names 2C-T-21, Aurora
Substitutive name 4-Fluoroethylthio-2,5-dimethoxyphenethylamine
Systematic name 4-(2-Fluoroethylthio)-2,5-dimethoxyphenethylamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 5 mg
Light 5 - 10 mg
Common 10 - 12 mg
Strong 12 - 15 mg
Heavy 15 mg +
Total 10 - 12 hours
Onset 90 - 120 minutes
Peak 3 - 4 hours
Offset 2 - 3 hours
After effects 2 - 4 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


2,5-Dimethoxy-4-ethylfluorothiophenethylamine (also known as 2C-T-21, or colloquially as Aurora) is a psychedelic substance of the phenethylamine chemical class that produces psychedelic effects when administered. It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule.

2C-T-21 was first synthesized by Alexander Shulgin and documented in his book PiHKAL ("Phenethylamines I Have Known and Loved"). The dosage range is listed as 8–12 mg. It is described in various reports as being generally relaxed and clear-headed with mild visual effects.[1] In Thanatos To Eros, 35 Years of Psychedelic Exploration, Myron Stolaroff describes it as "not psychedelic, but a wonderful energizer", along with displaying a notable lack of appetite suppression typically observed with members of its class. However he also mentions concerns regarding toxicity.[2]

In March 2004, a 22-year-old American male died after ingesting an unknown amount of 2C-T-21. This death became part of a two-year DEA investigation called "Operation Web Tryp" which ended with the arrests of 10 persons involved in the online distribution of research chemicals.[3] 2C-T-21 remains unscheduled in the United States.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-21, although a paper by Daniel Trachsel hypothesizes that one of its metabolites is the poison fluoroacetate.[4] It has little history of human usage. It is strongly advised to use harm reduction practices if using this substance.


2C-T-21, or 2,5-dimethoxy-4-ethylfluorothiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-T-21 contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring as well as an ethylfluoro thioether group attached to carbon R4 of the phenyl ring.

2C-T-21 belongs to the 2C family of phenethylamines, all of which contain methoxy groups on the 2 and 5 positions of the benzene ring.



This pharmacology section is incomplete.

You can help by adding to it.

2C-T-21's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

This compound, being similar in structure to 2C-T-2 and 2C-T-7 is also believed to potentially have MAOI properties.

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Visual effects

Cognitive effects

Auditory effects

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

On March 9, 2004, a 22-year-old American male consumed an unknown dose of 2C-T-21 by sticking his tongue into a vial of powder he had purchased online. He developed a temperature of 108 degrees Fahrenheit (42 degrees Celsius),[3] had a tonic-clonic seizure, and slipped into a coma before dying four days later.[citation needed] These symptoms are consistent with those seen in fluoroacetate poisoning, for which there is no known effective antidote.[5]

Fluoroacetate is hypothesized to be a metabolite of 2C-T-21.[4] Sub-lethal doses of fluoroacetate take up to four days to clear from the body.[6] As such, it is likely dangerous to take 2C-T-21 multiple days in a row as this poisonous metabolite will accumulate. Furthermore, sub-lethal doses may cause damage to tissue with high energy needs (e.g. the brain, gonads, heart, lungs, and fetus). This may account for the experience of a couple who became "convinced that it is toxic" in Stolaroff's book.[2]

There is no anecdotal evidence to suggest that a single, moderate dose of 2C-T-21 can cause negative health effects, although nothing can be guaranteed.

It is strongly discouraged to administer 2C-T-21 non-orally because this may cause vomiting, numerous negative side effects, or death at high doses.

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the accurate administration of the intended dose.

Tolerance and addiction potential

2C-T-21 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-T-21 is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T-21 presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-T-21 all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

If 2C-T-21 does have MAOI effects as commonly speculated, this could indicate that 2C-T-21 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.[7] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which releases neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Austria: 2C-T-21 is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).[citation needed]
  • Canada: As of October 31st, 2016; 2C-T-21 is a controlled substance (Schedule III) in Canada.[8]
  • Germany: 2C-T-21 is controlled under the NpSG[9] (New Psychoactive Substances Act) as of November 26, 2016.[10] Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.[11][12] The legislator considers it possible that orders of 2C-T-21 are punishable as an incitement to place it on the market.[13]
  • Switzerland: 2C-T-21 can be considered a controlled substance as a defined derivative of Phenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.[14]
  • United Kingdom: 2C-T-21 is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.[15]
  • United States: 2C-T-21 is technically not scheduled in the United States, but could be considered an analogue of 2C-T or 2C-T-7 and may therefore be considered a Schedule I drug under the Federal Analogue Act.[citation needed]

See also

External links


  1. Alexander Shulgin; Ann Shulgin (1991). "#49. 2C-T-21". PiHKAL: A Chemical Love Story. United States: Transform Press. ISBN 0963009605. OCLC 1166889264. 
  2. 2.0 2.1 Myron J. Stolaroff (1994). "Thanatos To Eros, 35 Years of Psychedelic Exploration". Multidisciplinary Association for Psychedelic Studies (MAPS). 
  3. 3.0 3.1 "DEA Announces Arrests Of Website: Operators Selling Illegal Designer Drugs". Drug Enforcement Administration (DEA). July 22, 2004. Archived from the original on October 22, 2017. 
  4. 4.0 4.1 Trachsel, Daniel. (2012) Fluorine in psychedelic phenethylamines, Drug Testing and Analysis, Vol. 4, Issue 7-8 (Special Issue: Psychedelic Substances), July-August 2012, pp. 577-590. DOI:10.1002/dta.413
  5. Proudfoot et al. (2006) Sodium Fluoroacetate Poisoning . Toxicological Reviews, 25 pp. 213–219.
  6. Eason et al. (1993) Sodium monofluoroacetate and alternative toxins for possum control, New Zealand Journal of Zoology, Vol. 20, Issue 4, pp. 329-334. DOI:10.1080/03014223.1993.10420354
  7. Gallardo-Godoy, A.; Fierro, A.; McLean, T. H.; Castillo, M.; Cassels, B. K.; Reyes-Parada, M.; Nichols, D. E. (2005). "Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling". Journal of Medicinal Chemistry. 48 (7): 2407–2419. doi:10.1021/jm0493109. eISSN 1520-4804. ISSN 0022-2623. OCLC 39480771. PMID 15801832. 
  8. "Regulations Amending the Food and Drug Regulations (Part J — 2C-phenethylamines)". Canada Gazette Part II (published May 4, 2016). 150 (9). April 15, 2016. ISSN 0045-4206. SOR/2016-72. 
  9. "Anlage NpSG" (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019. 
  10. "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF). Bundesgesetzblatt Jahrgang 2016 Teil I Nr. 55 (in German). Bundesanzeiger Verlag (published November 25, 2016). November 21, 2016. pp. 2615–2622. ISSN 0341-1095. OCLC 1004462279. 
  11. "§ 4 NpSG" (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019. 
  12. "§ 3 NpSG" (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019. 
  13. "Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Deutscher Bundestag. May 30, 2016. p. 20. Drucksache 18/8579. 
  14. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  15. "Schedule 2: Part I: Class A Drugs". "Misuse of Drugs Act 1971". UK Government. Retrieved August 20, 2020.