NM-2-AI - PsychonautWiki

NM-2-AI

Summary sheet: NM-2-AI
NM-2-AI
N-methyl-2-AI.svg
Chemical Nomenclature
Common names NM-2-AI
Substitutive name N-methyl-2-AI
Systematic name N-methyl-2,3-dihydro-1H-inden-2-amine
Class Membership
Psychoactive class Stimulant
Chemical class Amphetamine / Aminoindane
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 5 mg
Light 50 - 100 mg
Common 100 - 150 mg
Strong 150 - 200 mg
Heavy 200 mg +
Duration
Total 2 - 4 hours
Onset 30 - 60 minutes









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Alcohol
MXE
Dissociatives
DXM
MDMA
Stimulants
25x-NBOMe
25x-NBOH
Tramadol
MAOIs


NM-2-AI (N-methyl-2-aminoindane) is a lesser-known novel stimulant substance of the aminoindane class. It is structurally related to 2-AI and MDAI.

In comparison to 2-AI, this compound has a lower potency, a longer duration and very similar effects. It has recently become easily accessible through online research chemical vendors where it is sold as a designer drug.

Very little data exists for the effects, pharmacology, and toxicity of NM-2-AI. It is highly advised to use harm reduction practices if using this substance.

Chemistry

NM-2-AI, or N-methyl-2-AI, is the N-methylated derivative of 2-Aminoindane and is analogous to amphetamine. It features the R3 terminal carbon of the propane chain of amphetamine bound to the benzene ring. This creates an indane, a bicycle containing a benzene ring fused to a pentane ring. The amino group 2-AI shares with amphetamine is bound to R2 of the indane group. N-methyl-2-AI contains a methyl group bound to the amino group RN (for which it is named).

Pharmacology

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is speculation purely based upon its structure and subjective effect similarities to other stimulants such as amphetamine, methamphetamine and 2-FMA. It is speculated that NM-2-AI most likely acts as both a dopamine and norepinephrine releasing agent. This means it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
 

After effects
 

Cognitive effects
 


Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Toxicity and harm potential

The toxicity and long-term health effects of recreational NM-2-AI use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because NM-2-AI has very little history of human usage. Anecdotal evidence from people who have tried NM-2-AI within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other stimulants, the chronic use of NM-2-AI can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of NM-2-AI develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). NM-2-AI presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of NM-2-AI all stimulants will have a reduced effect.

Psychosis

Main article: Stimulant psychosis

Abuse of compounds within the stimulant class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, or delusions).[1] A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely.[1][2] The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis.[1]

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

 

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

NM-2-AI is currently believed to be a grey area compound within most parts of the world. This means that it is not known to be specifically illegal within any country but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.

  • Germany: NM-2-AI is controlled under the NpSG (New Psychoactive Substances Act)[5] as of November 26, 2016.[6] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[7]
  • Switzerland: NM-2-AI is a controlled substance specifically named under Verzeichnis E.[8]
  • United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[9]

See also

External links

References

  1. 1.0 1.1 1.2 Shoptaw, S. J., Kao, U., Ling, W. (21 January 2009). Cochrane Drugs and Alcohol Group, ed. "Treatment for amphetamine psychosis". Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD003026.pub3. ISSN 1465-1858. 
  2. Hofmann, F. G. (1983). A handbook on drug and alcohol abuse: the biomedical aspects (2nd ed ed.). Oxford University Press. ISBN 9780195030563. 
  3. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. eISSN 1937-6995. ISSN 1556-9039. OCLC 163567183. 
  4. Gillman, P. K. (2005). "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity". British Journal of Anaesthesia. 95 (4): 434–441. doi:10.1093/bja/aei210 . eISSN 1471-6771. ISSN 0007-0912. OCLC 01537271. PMID 16051647. 
  5. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 23, 2019. 
  6. "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 23, 2019. 
  7. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 23, 2019. 
  8. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  9. Psychoactive Substances Act 2016