Cognitive fatigue
Cognitive fatigue (also called exhaustion, tiredness, lethargy, languidness, languor, lassitude, and listlessness) is medically recognized as a state usually associated with a weakening or depletion of one's mental resources.[1][2] The intensity and duration of this effect typically depends on the substance consumed and its dosage. It can also be further exacerbated by various factors such as a lack of sleep[3] or food[4]. These feelings of exhaustion involve a wide variety of symptoms which generally include some or all of the following effects:
- Analysis depression
- Motivation depression
- Thought deceleration
- Short term memory suppression
- Thought disorganization
- Language depression
- Creativity depression
Cognitive fatigue is most commonly induced under the influence of moderate dosages of antipsychotic compounds,[5][6] such as quetiapine, haloperidol, and risperidone. However, it can also occur during the withdrawal symptoms of many depressants,[7] and during the offset of many stimulants[8].
Psychoactive substances
Compounds within our psychoactive substance index which may cause this effect include:
- 2-Aminoindane
- 2-FA
- 2-FEA
- 2-FMA
- 2C-B-FLY
- 3,4-CTMP
- 3-FA
- 3-FEA
- 3-FMA
- 3-FPM
- 3-MMC
- 4-FA
- 4-FMA
- 4F-EPH
- 4F-MPH
- 5-APB
- 5-MAPB
- 6-APB
- 6-APDB
- A-PHP
- A-PVP
- Alcohol
- Amphetamine
- Baclofen
- Bromo-DragonFLY
- Butylone
- Caffeine
- Clonidine
- Cocoa
- Cyclazodone
- Datura
- Desoxypipradrol
- Dextromethorphan
- Dichloropane
- Diphenhydramine
- ETH-CAT
- Ephylone
- Ethylone
- Ethylphenidate
- Grayanotoxin
- Haloperidol
- Hexedrone
- Isopropylphenidate
- Lisdexamfetamine
- MDA
- MDAI
- MDEA
- MDMA
- MDPV
- Mephedrone
Experience reports
Annectdotal reports which describe this effect with our experience index include:
- Experience:12 mg AMT - Nicely Surprised
- Experience:150mg MDMA + 20mg 2C-B - I designed it this way myself
- Experience:4 Days Sleep Deprivation - Progression of Sleep Deprivation Visuals Over Time
- Experience:40mg + Syrian Rue (unknown dosage) - My one bad trip
- Experience:4F-EPH (15mg) - Untitled
- Experience:6g mimosa / 2.5 g syrian rue - Best cake I've had for a while
See also
External links
References
- ↑ "Glossary of Technical Terms". Diagnostic and statistical manual of mental disorders (5th ed.): 821. 2013. doi:10.1176/appi.books.9780890425596.GlossaryofTechnicalTerms.
- ↑ Mizuno, Kei; Tanaka, Masaaki; Yamaguti, Kouzi; Kajimoto, Osami; Kuratsune, Hirohiko; Watanabe, Yasuyoshi (2011). "Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity". Behavioral and Brain Functions. 7 (1): 17. doi:10.1186/1744-9081-7-17. ISSN 1744-9081.
- ↑ Alhola, P., & Polo-Kantola, P. (2007). Sleep deprivation: Impact on cognitive performance. Neuropsychiatric disease and treatment. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656292/
- ↑ Kim, Jin Young; Kang, Seung Wan (2017). "Relationships between Dietary Intake and Cognitive Function in Healthy Korean Children and Adolescents". Journal of Lifestyle Medicine. 7 (1): 10–17. doi:10.15280/jlm.2017.7.1.10. ISSN 2234-8549.
- ↑ Seo, Rubo J.; MacPherson, Holly; Young, Allan H. (2010). "Atypical Antipsychotics and Other Therapeutic Options for Treatment of Resistant Major Depressive Disorder". Pharmaceuticals. 3 (12): 3522–3542. doi:10.3390/ph3123522. ISSN 1424-8247.
- ↑ Wittkampf, Laura Christina; Arends, Johannes; Timmerman, Leo; Lancel, Marike (2012). "A review of modafinil and armodafinil as add-on therapy in antipsychotic-treated patients with schizophrenia". Therapeutic Advances in Psychopharmacology. 2 (3): 115–125. doi:10.1177/2045125312441815. ISSN 2045-1253.
- ↑ Chaudhuri, Abhijit; Behan, Peter O (2000). "Fatigue and basal ganglia". Journal of the Neurological Sciences. 179 (1-2): 34–42. doi:10.1016/S0022-510X(00)00411-1. ISSN 0022-510X.
- ↑ Lago, Jesus A.; Kosten, Thomas R. (1994). "Stimulant withdrawal". Addiction. 89 (11): 1477–1481. doi:10.1111/j.1360-0443.1994.tb03746.x. ISSN 0965-2140.