Desoxypipradrol

Desoxypipradrol is a synthetic stimulant of the substituted benzylpiperidine class. It contains a substituted phenethylamine skeleton with an additional phenyl ring bound to R_β. The terminal amino group of the phenethylamine chain is incorporated into a piperidine ring. As a result of lacking polar functional groups it is a highly lipophilic molecule, giving it an extremely long-lasting multi-day duration of action that is rarely observed in stimulant drugs -- notably with the exception of MDPV.

Desoxypipradrol primarily acts as a norepinephrine-dopamine reuptake inhibitor (NDRI)^[1], but one with an unusually high potency, extreme duration and unpredictable dose-response for a stimulant drug. These risks likely owe themselves to its abnormally high lipophilicity and long elimination half-life, which among other things likely increases the relative risk it has in triggering states of stimulant psychosis when abused, with which it has been demonstrated in humans to be an uncommonly low threshold.

Desoxypipradrol possesses an unusually high potency, extreme duration and unpredictable dose-response for a stimulant drug. However, due to the relative "cleanness" or subtleness of the stimulation some reports indicate a tendency in users to redose it compulsively until dangerous amounts end up becoming consumed, which can lead to overdose, hospitalizations, and even fatalities. Those who wish to experiment with this compound are advised to use proper harm-reduction practices and approach with this substance with extreme caution (such as not redosing, and using volumetric dosing techniques).

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: Desoxypipradrol

Toxicity

Desoxypipradrol may be quantitated in blood, plasma or urine by liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalized patients or to provide evidence in a medicolegal death investigation. Blood or plasma desoxypipradrol concentrations are expected to be in a range of 10–50 μg/L in persons using the drug recreationally, >100 μg/L in intoxicated patients and >600 μg/L in victims of acute overdosage.^[2]

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

In terms of its tolerance, desoxypipradrol can be used for multiple days in a row for extended periods of time. Acute tolerance to many of the effects of desoxypipradrol develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). desoxypipradrol presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of desoxypipradrol all stimulants will have a reduced effect.

As with other stimulants, the chronic use of desoxypipradrol can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

User reports suggest that compared to many other stimulants, desoxypipradrol has some unique and atypical hazards that can accompany its misuse -- especially when it is eye-balled, not dosed volumetrically, or otherwise handled without the proper degree of caution. Desoxypipradrol, like other stimulants, increases dopamine levels in the brain which can lead to severe manic psychosis in the short-term in addition to persisting dopamine receptor down regulation in the long-term.

Psychosis

User reports indicate that chronic abuse or single exposure overdose of desoxypipradrol can potentially lead to psychosis more readily than the vast majority of stimulants. Psychotic symptoms from desoxypipradrol can include hearing voices, visual hallucinations, urges to harm oneself, severe anxiety, mania, grandiosity, paranoid delusions, confusion, increased aggression, and irritability.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• 25x-NBOMe & 25x-NBOH - 25x compounds are highly stimulating and physically straining. Combinations with Desoxypipradrol should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
• Alcohol - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• DXM - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
• MDMA - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
• MXE - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
• Dissociatives - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
• Stimulants - Desoxypipradrol may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
• Tramadol - Tramadol is known to lower the seizure threshold^[3] and combinations with stimulants may further increase this risk.
• MDMA - The neurotoxic effects of MDMA may be increased when combined with other stimulants.

• MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, and some antidepressants.^[4]
• Cocaine - This combination may increase strain on the heart.

• China: As of October 2015, 2-DPMP is a controlled substance in China.^[5]
• Germany: Desoxypipradrol is controlled under Anlage II BtMG (Narcotics Act, Schedule II)^[6] as of December 13, 2014.^[7] It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.^[8]
• Russia: Deoxypipradol is entered in the Schedule I prohibited substance as (Пиперидин-2-ил)дифенилметан.^[9]
• Switzerland: Desoxypipradol is not controlled under Buchstabe A, B, C and D. It could be considered legal.^[10]
• United Kingdom: As of November 4, 2010, the UK Home Office announced a ban on the importation of 2-DPMP, following a recommendation from the ACMD.^[11] Prior to the import ban, desoxypipradrol was sold as a 'legal high' in several products. Its use lead to several Emergency Department visits which prompted the UK government to commission a review from the ACMD. The Advisory Council on the Misuse of Drugs stated in their report^[12] that: "there are serious harms associated with 2-DPMP... typically prolonged agitation (lasting up to 5 days after drug use which is sometimes severe, requiring physical restraint), paranoia, hallucinations and myoclonus (muscle spasms/twitches)." 2-DPMP was due to become a class B drug^[13] on March 28, 2012,^[14] but the bill was scrapped as two steroids deemed not to be abusable were included in the bill but were later recommended to remain uncontrolled.^[15] There was a new discussion about its fate on April 23, 2012, where it was decided that the bill would be rewritten and 2-DPMP would still be banned. It was also decided that the bill would be a blanket ban of related chemicals.^[16] Desoxypipradrol was eventually made a class B drug and placed in Schedule I on June 13, 2012.^[17] There were no recorded deaths from the drug between the banning of its import and the banning of its possession. "Esters and ethers of pipradrol" were controlled with the same amendment as class C drugs.^[17]
• United States: Desoxypipradrol is unscheduled in the United States, and thus legal to possess and import. However, it is an analog of pipradol which is a Schedule IV Controlled Substance.^{[citation needed]}

• Responsible use
• Stimulants
• Research chemical

• Desoxypipradrol (Wikipedia)
• Desoxypipradrol (Isomer Design)