Hexedrone

Hexedrone is a cathinone, which is closely related to amphetamines, but have a ß-substituted ketone group as well. Relative to regular cathinone, which can be found in the Khat plant, hexedrone consists of two added substitutions. At the R₂ position, a n-Butyl substitution forms a hexan chain. The second substitution is a Methyl group, that's attached to the amine (R₄), thus forming N-Methyl.

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structure and subjective effect similarities to other cathinones such as pentedrone and others. Hexedrone most likely acts as both a dopamine and norepinephrine reuptake inhibitor. This allows dopamine and norepinephrine to build up within the brain, resulting in stimulating and euphoric effects.

The decreased potency, compared to both pentedrone as well as ethyl-hexedrone can be easily explained. Compared to pentedrone, there is a larger non-polar side chain. Ethyl-hexedrone has an ethyl group, instead of a methyl, which results in a significantly shifted electronegativity.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Since hexedrone has been insufficiently studied and most data consists of speculation and user experiences, one should be especially cautious when it comes to the risks and harm this substance may pose, especially in terms of seriouslong-term health hazards.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other stimulants, the chronic use of Hexedrone can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of hexedrone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Hexedrone presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of Hexedrone all stimulants will have a reduced effect.

• Brazil: On September 7, 2018, all Cathinone analogues are controlled substances considered illegal to possess, use and distribute. This was made possible due to a blanket ban law appended to Portaria SVS/MS nº 344.^[1]
• Germany: Hexedrone is controlled under the NpSG (New Psychoactive Substances Act)^[2] as of November 26, 2016.^[3] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.^[4]
• Switzerland: Hexedrone can be considered a controlled substance as a defined derivative of Cathinone under Verzeichnis E point 1. It is legal when used for scientific or industrial use.^[5]
• United Kingdom: Hexedrone is a Class B drug in the United Kingdom as a result of the cathinone catch-all clause.^[6]

• Responsible use
• Research chemical
• Stimulant
• Substituted cathinone

• Hexedrone (Wikipedia)
• Hexedrone (Isomer Design)