4F-EPH - PsychonautWiki
Summary sheet: 4F-EPH
4F-EPH
4F-EPH.svg
Chemical Nomenclature
Common names 4F-EPH, 4-FEPH
Substitutive name 4-Fluoroethylphenidate
Systematic name Ethyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate
Class Membership
Psychoactive class Stimulant
Chemical class Phenidate
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold < 5 mg
Light 5 - 10 mg
Common 10 - 15 mg
Strong 15 - 30 mg
Heavy 30 mg +
Duration
Total 5 - 6 hours
Onset 10 - 25 minutes
After effects 4 - 12 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Alcohol
MXE
Dissociatives
DXM
MDMA
Stimulants
25x-NBOMe
25x-NBOH
Tramadol
MAOIs


4-Fluoroethylphenidate (commonly known as 4F-EPH) is a novel synthetic stimulant of the phenidate chemical class that produces long-lasting euphoric and stimulating effects associated with potent monoamine reuptake inhibitors when administered. It is a closely related structural analog of the commonly prescribed ADHD drug methylphenidate (known by the brand-names Ritalin and Concerta) as well as a designer drug analog ethylphenidate. Based on its similarities to other memebers of this class, it is speculated to exert its activity as some form of double or triple monoamine reuptake inhibitor.

Like other members of the substituted phenidate family, anecdotal reports suggest that 4F-EPH can be corrosive to the nasal cavities, albeit not to the degree of ethylphenidate.

4F-EPH has little to no history of recreational use and has yet to be documented being sold on the streets. It was initially developed as a replacement and successor for compounds like ethylphenidate, which became illegal in the United Kingdom on April 2015, and later 4F-MPH. In 2016, it became made available for sale on the online gray market as a research chemical.

Due to its potent, long-lasting stimulant effect, likely habit-forming properties as well as unknown short and long-term toxicity profile, it is strongly recommended that one use proper harm reduction practices if choosing to use this substance.

Chemistry

4F-EPH, or 4-fluoroethylphenidate, is a synthetic molecule of the phenidate and substituted phenethylamine classes. It contains a phenethylamine core featuring a phenyl ring bound to an amino -NH2 group through an ethyl chain. It is structurally similar to amphetamine, featuring a substitution at Rα which is incorporated into a piperidine ring ending at the terminal amine of the phenethylamine chain. It contains an ethyl acetate bound to Rβ of its structure and is fluorinated at R4 of its phenyl ring.

4F-EPH is the 4-substituted flourine derivative of ethylphenidate, and is structurally different to methylphenidate by elongation of the carbon chain and the addition of a fluorine group. Ethyl- regards the side chain of two carbon atoms, phen- indicates the phenyl ring, id- is contracted from a piperidine ring, and -ate indicates the acetate group containing the oxygens. 4F-EPH is a chiral compound, presumably produced as a racemic mixture.

Pharmacology

 

This pharmacology section is incomplete.

You can help by adding to it.

4F-EPH is believed to act as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate,[1][2][3] meaning that it effectively boosts the levels of dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine to accumulate within the certain focalized regions of the brain, resulting in stimulating and euphoric effects.

Subjective effects

 
This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
 

Cognitive effects
 

After effects
 

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Toxicity and harm potential

 

This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

The toxicity and long-term health effects of recreational 4F-EPH use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4F-EPH is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 4F-EPH suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other stimulants, the chronic use of 4F-EPH can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of 4F-EPH develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). 4F-EPH presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of 4F-EPH all stimulants will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

 

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Germany: 4-Fluoroethylphenidate is controlled under the NpSG (New Psychoactive Substances Act)[6] as of November 26, 2016.[7] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[8]
  • Switzerland: 4F-EPH is a controlled substance specifically named under Verzeichnis E.[9]
  • Turkey: 4F-EPH is a classed as drug and is illegal to possess, produce, supply, or import.[10]
  • United Kingdom: 4-Fluoroethylphenidate is a class B drug in the UK as of May 31st 2017, making it illegal to possess, produce or supply. [11]

See also

External links

References

  1. Davies, H. M. L., Hopper, D. W., Hansen, T., Liu, Q., Childers, S. R. (5 April 2004). "Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites". Bioorganic & Medicinal Chemistry Letters. 14 (7): 1799–1802. doi:10.1016/j.bmcl.2003.12.097. ISSN 0960-894X. 
  2. Misra, M., Shi, Q., Ye, X., Gruszecka-Kowalik, E., Bu, W., Liu, Z., Schweri, M. M., Deutsch, H. M., Venanzi, C. A. (15 October 2010). "Quantitative structure-activity relationship studies of threo-methylphenidate analogs". Bioorganic & Medicinal Chemistry. 18 (20): 7221–7238. doi:10.1016/j.bmc.2010.08.034. ISSN 1464-3391. 
  3. Singh, S. (8 March 2000). "Chemistry, design, and structure-activity relationship of cocaine antagonists". Chemical Reviews. 100 (3): 925–1024. doi:10.1021/cr9700538. ISSN 1520-6890. 
  4. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. eISSN 1937-6995. ISSN 1556-9039. OCLC 163567183. 
  5. Gillman, P. K. (2005). "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity". British Journal of Anaesthesia. 95 (4): 434–441. doi:10.1093/bja/aei210 . eISSN 1471-6771. ISSN 0007-0912. OCLC 01537271. PMID 16051647. 
  6. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 23, 2019. 
  7. "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 23, 2019. 
  8. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 23, 2019. 
  9. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  10. Cumhurbaşkanı Kararı CK Karar Sayısı : 1335 | https://resmigazete.gov.tr/eskiler/2019/07/20190720-19.pdf
  11. The Misuse of Drugs Act 1971 (Amendment) Order 2017