2C-T - PsychonautWiki

2C-T

Summary sheet: 2C-T
2C-T
2C-T.svg
Chemical Nomenclature
Common names 2C-T, Tesseract
Substitutive name 4-methylthio-2,5-dimethoxyphenethylamine
Systematic name 2-[4-(Methylthio)-2,5-dimethoxyphenyl]ethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 20 mg
Light 40 - 60 mg
Common 60 - 100 mg
Strong 100 - 120 mg
Heavy 125 mg +
Duration
Total 3 - 6 hours
Onset 30 - 45 minutes
Peak 30 - 115 minutes
Offset 1 - 2 hours
After effects 1 - 2 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions

2,5-Dimethoxy-4-methylthiophenethylamine (also known as 2C-T) is a lesser-known psychedelic substance of the phenethylamine class. It is a member of the 2C-x family of psychedelic phenethylamines, all of which are close relatives to mescaline. It is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is not fully understood.

2C-T was first synthesized as part of a collaboration between researchers David E. Nichols and Alexander Shulgin.[1] Its effects and synthesis is described in Shulgin's 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").[2]

2C-T's subjective effects are not well-characterized. Preliminary anecdotal reports appear to indicate it has some of the psychedelic effects of 2C-T-2 and 2C-T-7. The effects of 2C-T have been described as being less visual and more tactile.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T, and it has a relatively short history of human usage. It is highly advised to use harm reduction practices if using this substance.

History and culture

 

This History and culture section is a stub.

As a result, it may contain incomplete or wrong information. You can help by expanding it.

It was first synthesized and studied through a collaboration between David E. Nichols and Alexander Shulgin.[3] However, 2C-T is almost unknown on the black market and is rarely sold online.

Chemistry

2C-T is in a class of compounds commonly known as phenethylamines, and is the 4-methylthio analogue of 2C-O, a positional isomer of mescaline. It is also the 2C analog of Aleph. The systematic name of the chemical is 2-(2,5-dimethoxy-4-(methylthio)phenyl)ethanamine. The CAS number of 2C-T is 61638-09-3.

2C-T, or 2,5-dimethoxy-4-methylthiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through a methyl chain. 2C-T belongs to the 2C family of phenethylamines which contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring. 2C-T is also substituted at R4 with an methyl thioether group.

Pharmacology

Further information: Serotonergic psychedelic

The mechanism of action that produces 2C-T’s hallucinogenic and entheogenic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the 5-HT2A receptor as a partial agonist. This mechanism of action is shared by many other psychedelic phenethylamines and tryptamines.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Being similar in structure to 2C-T-2 and 2C-T-7, this compound may have some MAOI properties.

Subjective effects

 
 This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

The effects of 2C-T have been described as being less visual and more in the body.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
 

Visual effects
 

Cognitive effects
 

Auditory effects
 

Transpersonal effects
 


Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

 

This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

Further information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 2C-T use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.

Anecdotal reports suggest that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed.

It is strongly recommended that one use harm reduction practices when using this substance.

Dependence and abuse potential

2C-T is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-T is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-T all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Although only speculative, it is worth noting that if 2C-T does have MAOI effects this could indicate that 2C-T is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.[4] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which promotes the release of neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:

Legal status

  • Canada: 2C-T would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[5]
  • Germany: 2C-H is controlled under the NpSG[6] (New Psychoactive Substances Act) as of November 26, 2016.[7] Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.[8][9] The legislator considers it possible that orders of 2C-H are punishable as an incitement to place it on the market.[10]
  • United Kingdom: 2C-T is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.[11]
  • United States: 2C-T is a Schedule 1 drug in the U.S., making it illegal to possess, manufacture, or import.[citation needed]

See also

External links

Discussion

References

  1. ↑ Nichols, D. E.; Shulgin, A. T. (1976). "Sulfur Analogs of Psychotomimetic Amines". Journal of Pharmaceutical Sciences. 65 (10): 1554–1556. doi:10.1002/jps.2600651040. eISSN 0022-3549. ISSN 1520-6017. OCLC 01754726. PMID 978423. 
  2. ↑ Alexander Shulgin; Ann Shulgin (1991). "#39. 2C-T". PiHKAL: A Chemical Love Story. United States: Transform Press. ISBN 0963009605. OCLC 1166889264. 
  3. ↑ Nichols DE, Shulgin AT (October 1976). "Sulfur analogs of psychotomimetic amines". J Pharm Sci. 65 (10): 1554–6. CiteSeerX 10.1.1.687.8486. doi:10.1002/jps.2600651040. PMID 978423.
  4. ↑ Gallardo-Godoy, A.; Fierro, A.; McLean, T. H.; Castillo, M.; Cassels, B. K.; Reyes-Parada, M.; Nichols, D. E. (2005). "Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling". Journal of Medicinal Chemistry. 48 (7): 2407–2419. doi:10.1021/jm0493109. eISSN 1520-4804. ISSN 0022-2623. OCLC 39480771. PMID 15801832. 
  5. ↑ "Schedule III". Controlled Drugs and Substances Act (CDSA). Isomer Design. Retrieved October 10, 2020. 
  6. ↑ "Anlage NpSG" (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019. 
  7. ↑ "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF). Bundesgesetzblatt Jahrgang 2016 Teil I Nr. 55 (in German). Bundesanzeiger Verlag (published November 25, 2016). November 21, 2016. pp. 2615–2622. ISSN 0341-1095. OCLC 1004462279. 
  8. ↑ "§ 4 NpSG" (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019. 
  9. ↑ "§ 3 NpSG" (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019. 
  10. ↑ "Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Deutscher Bundestag. May 30, 2016. p. 20. Drucksache 18/8579. 
  11. ↑ "Schedule 2: Part I: Class A Drugs". "Misuse of Drugs Act 1971". UK Government. Retrieved August 20, 2020. 


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