4-AcO-DET

4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R₄ of its indole heterocycle with an acetoxy (AcO) functional group CH₃COO−. It also contains two ethyl chains bound to the terminal amine R_N of its tryptamine backbone (DET).

4-AcO-DET is the N-substituted diethyl homolog of 4-HO-DMT (psilocin). 4-AcO-DET is the acetate ester analog of DET and the N-substituted diethyl analog of 4-AcO-DMT.^[2] It is a higher homolog of 4-AcO-DMT and 4-AcO-MET.

4-substituted acetylated tryptamines such as 4-AcO-DET, 4-AcO-MET, and 4-AcO-DMT are hypothesized to principally act as a prodrug for their respective hydrolyzed counterparts (e.g. 4-HO-DMT, 4-HO-MET and 4-HO-DET). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.^{[citation needed]}

Like with most psychedelic tryptamines, 4-AcO-DET is thought to act principally as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from 4-AcO-DET's binding efficacy at the 5-HT_2A receptors.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: 4-AcO-DET

The toxicity and long-term health effects of recreational 4-AcO-DET has not been studied in any scientific context and the exact toxic dose is unknown. This is because 4-AcO-DET is a research chemical with a very limited history of human usage. However, it is assumed to have a similar toxicity profile as psilocybin due to their structural similarity.

Anecdotal reports from those who have tried 4-AcO-DET suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

Although no formal studies have been conducted, it is believed that 4-AcO-DET is not habit-forming and the desire to use it can actually decrease with use.

Tolerance to the effects of 4-AcO-DET is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-AcO-DET presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-AcO-DET all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
• Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 4-AcO-DET. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
• Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.^{[citation needed]}
• Tramadol - Tramadol is well-documented to lower the seizure threshold^[3] and psychedelics may act to trigger seizures in susceptible individuals.^{[citation needed]}

Due to its relative obscurity, the possession and sale of 4-AcO-DET is unscheduled in most countries.

• Germany: Because it is an ester of DET, 4-AcO-DET is controlled under Anlage I BtMG (Narcotics Act, Schedule I)^[4] as of January 24, 1974.^[5] It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.^[6]
• Japan: 4-AcO-DET is a controlled substance in Japan effective July 29th, 2015.^[7]
• Switzerland: 4-AcO-DET is a controlled substance specifically named under Verzeichnis E.^[8]
• Sweden: 4-AcO-DET was classified under the Act on the Prohibition of Certain Goods Dangerous to Health on November 1, 2005, making it illegal to sell or possess.^[9]
• Turkey: 4-AcO-DET is a classed as drug and is illegal to possess, produce, supply, or import.^[10][11]
• United Kingdom: 4-AcO-DET is a Class A drug in the UK as it is an ester of the drug 4-HO-DET, which is a Class A drug as a result of the tryptamine catch-all clause.^[12]
• United States: 4-AcO-DET is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT) which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.^{[citation needed]}

• Responsible use
• Research chemical
• Hallucinogen
• Tryptamine
• 4-HO-DET
• 4-AcO-DMT
• 4-AcO-MET

• 4-AcO-DET (Wikipedia)
• 4-AcO-DET (Erowid Vault)
• 4-AcO-DET (Isomer Design)

Discussion

• The Big & Dandy 4-AcO-DET Thread (Bluelight)