2,5-DMA

2,5-DMA, or 2,5-dimethoxyamphetamine, is a substituted phenethylamine and amphetamine featuring a phenyl ring bound to an amino (NH₂) group through an ethyl chain along with a methyl group at the alpha carbon. 2,5-DMA contains methoxy functional groups CH₃O- attached to carbons R₂ and R₅ as well as a hydrogen atom attached to carbon R₄ of the phenyl ring.

2,5-DMA belongs to the DOx family of amphetamines, which contain methoxy groups on the 2 and 5 positions of the benzene ring, and is also their simplest member. It is commonly used as a precursor to other compounds of the DOx family, including DOB, DOI and DON.

There is no record of 2,5-DMA trials in humans and very little data exists about the pharmacological properties, metabolism, and toxicity of 2,5-DMA.

2,5-DMA appears to be primarily stimulating in its effects rather than being a psychedelic. It does not seem to have noteable sensory enhancement effects.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index.

The toxicity and long-term health effects of recreational 2,5-DMA use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2,5-DMA is a research chemical with very little history of human usage.

Anecdotal reports from those who have tried 2,5-DMA suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance so as to ensure the accurate administration of the intended dose.

Tolerance and addiction potential

Although no formal studies have been conducted, it is not unreasonable to assume that as is the case with psychedelics in general, 2,5-DMA is not habit-forming and that the desire to use it can actually decrease with use. However, it's stimulating properties do provide a possible risk of addiction which would be associated with other stimulants.

Tolerance to the effects of 2,5-DMA is built after ingestion over the couse of multiple days. After that, it takes about 3-5 days for the tolerance to be reduced to half and 7-10 days to be back at baseline (in the absence of further consumption). 2,5-DMA may present cross-tolerance, although unlikely, with all psychedelics, meaning that after the consumption of 2,5-DMA all psychedelics will have a reduced effect. It may also produce tolerance to stimulants as well.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
• Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 2,5-DMA. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
• Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.^{[citation needed]}
• Tramadol - Tramadol is well-documented to lower the seizure threshold^[2] and psychedelics may act to trigger seizures in susceptible individuals.^{[citation needed]}

• Germany: 2,5-DMA is controlled under the NpSG^{[citation needed]} (New Psychoactive Substances Act) as of November 26, 2016.^[3] Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.^[4][5] The legislator considers it possible that orders of 2C-H are punishable as an incitement to place it on the market.^[6]
• Switzerland: 2,5-DMA can be considered a controlled substance as a defined derivative of Phenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.^[7]
• United Kingdom: 2,5-DMA is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.^[8]
• United States: 2,5-DMA could be considered an analog of 2C-H or amphetamine, which could make it illegal under the Federal Analog Act.^{[citation needed]}

• Responsible use
• Substituted amphetamines
• DOx
• 2C-H

• Dimethoxyamphetamine (including 2,5-DMA) (Wikipedia)
• 2,5-DMA (PiHKAL)
• 2,5-DMA (PiHKAL / Isomer Design)