Talk:Phenylephrine
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| Summary sheet: Phenylephrine |
| Phenylephrine | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Common names | Phenylephrine | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Substitutive name | Neo-synephrine, m-Synephrine, β-HO-N-Me-3-HPEA | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Systematic name | 3-[1-Hydroxy-2-(methylamino)ethyl]phenol | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Class Membership | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Psychoactive class | Stimulant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical class | Phenethylamine | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Routes of Administration | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Phenylephrine is used as a decongestant sold as an oral medicine or as a nasal spray. It is a common ingredient in over-the-counter decongestants in the United States.
Phenylephrine is used as an alternative to pseudoephedrine as a decongestant, whose availability has been restricted due to a potential for use in the illicit synthesis of Methamphetamine . Its efficacy as an oral decongestant has been questioned, with several independent studies finding that it provided no more relief to sinus congestion than a placebo.
History and culture
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This History and culture section is a stub. As a result, it may contain incomplete or wrong information. You can help by expanding it. |
Phenylephrine was patented in 1927 and came into medical use in 1938. It is available as a generic medication
Pharmacology
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This pharmacology section is incomplete. You can help by adding to it. |
Phenylephrine is a sympathomimetic drug, which means that it mimics the actions of epinephrine (commonly known as adrenaline) or norepinephrine. Phenylephrine selectively binds to alpha-1 receptors which causes venous and arterial vasoconstriction.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects 
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- Nasal decongestion
- Pupil dilation - Most common when used in eye drops
- Increased blood pressure
- Abnormal heartbeat - This effect is most prevalent in high doses
- Headache - This effect is most prevalent in high doses
- Skin flushing
- Appetite suppression
- Dizziness - This effect is most prevalent in high doses
- Nausea
Cognitive effects 
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- Wakefulness
- Anxiety - This effect is most prevalent in high doses
- Insomnia - This effect is most prevalent in high doses
Experience reports
There are currently 0 experience reports which describe the effects of this substance in our experience index.
Additional experience reports can be found here:
Toxicity and harm potential
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This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. |
It is strongly recommended that one use harm reduction practices when using this substance.
Lethal dosage
The median lethal dose of phenylephrine taken orally at which 50% of participants die (LD50) for rats is 350mg/kg
Tolerance and addiction potential
Non-addictive with a low potential of abuse
Dangerous interactions
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This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it. |
The increase in blood pressure effect of phenylephrine may be increased by drugs such as monoamine oxidase inhibitors, tricyclic antidepressants, and hydrocortisone. Patients taking these medications may need a lower dose of phenylephrine to achieve a similar increase in blood pressure.
Drugs that may decrease the effects of phenylephrine may include calcium channel blockers, ACE inhibitors and benzodiazepines. Patients taking these medications may need a higher dose of phenylephrine to achieve a comparable increase in blood pressure.
Legal status
- Australia: Phenylephrine is a Schedule 2 (Pharmacy medicine) drug.
- United Kingdom: Phenylephrine is an OTC drug.
- United States: Phenylephrine is an OTC drug.