Creatine

Creatine is a nitrogenous amino acid produced endogenously and synthesized for consumption. Creatine is structurally comprised of an acetic acid group, a two carbon chain with both a ketone and hydroxyl group bonded to one of the carbons. This acetic acid group is connected at R₂ to a methyl substituted amine group, which in turn is also bound to a carbon atom substituted with one double bonded nitrogen and one single-bonded nitrogen constituent. Synthetic creatine is usually made from sarcosine (or its salts) and cyanamide which are combined in a reactor with catalyst compounds. The reactor is heated and pressurized, causing creatine crystals to form. The crystalline creatine is then purified by centrifuge and vacuum dried. The dried creatine compound is milled into a fine powder for improved bioavailability. Milling techniques differ, resulting in final products of varying solubility and bioavailability. For instance, creatine compounds milled to 200 mesh are referred to as micronized.^[1]

Creatine is an endogenous molecule that stores high-energy phosphate groups in the form of phosphocreatine (creatine phosphate). During periods of stress or strenuous exercise, phosphocreatine releases energy to aid cellular function. This is what causes strength increases after creatine supplementation, but this action can also aid the brain, bones, muscles, and liver. Most of the benefits of creatine are provided through this mechanism.^[2]

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

In comparison to the effects of other nootropics such as noopept, this compound can be described as conferring both physical stimulation and cognitive stimulation.

There are no clinically significant side-effects of creatine supplementation acutely. Numerous trials have been conducted in humans with varying dosages, and the side-effects have been limited to gastrointestinal distress (from too much creatine consumption at once) and cramping (from insufficient hydration).

Studies that use a dosage range typical of creatine supplementation (in the range of 5g a day following an acute loading period) note increases to total body water of 6.2% (3.74lbs) over nine weeks, and 1.1kg (2.42 lbs) over 42 days.^[3] This effect may be responsible for creatine's capability to increase perceived body weight.

Regardless, it is strongly recommended that one is familiar with harm reduction practices when using creatine.

Tolerance and addiction potential

Creatine is not habit-forming with a low potential for abuse. It does not seem to be capable of causing psychological or physiological dependence among users.

Tolerance to the effects of creatine are not built after ingestion as with most other psychoactive substances. There are many anecdotal reports of people ingesting this substance for prolonged periods of time with no tolerance build up.

Creatine is freely available to possess and distribute and is approved in most countries as a dietary supplement.

• M’Swiney, B. A. (1915). Creatine and creatinine. The Dublin Journal of Medical Science, 140(3), 175–191. https://doi.org/10.1007/BF02964439
• Francaux, M., & Poortmans, J. R. (1999). Effects of training and creatine supplement on muscle strength and body mass. European Journal of Applied Physiology and Occupational Physiology, 80(2), 165–168. https://doi.org/10.1007/s004210050575
• Persky, a M., & Brazeau, G. a. (2001). Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacological Reviews, 53(2), 161–176. https://doi.org/10.1124/pharmrev1
• Metzl, J. D., Small, E., Levine, S. R., & Gershel, J. C. (2001). Creatine Use Among Young Athletes. PEDIATRICS, 108(2), 421–425. https://doi.org/10.1542/peds.108.2.421
• Brosnan, J. T., & Brosnan, M. E. (2007). Creatine: endogenous metabolite, dietary, and therapeutic supplement. Annual Review of Nutrition, 27(December), 241–261. https://doi.org/10.1146/annurev.nutr.27.061406.093621
• Hezave, A. Z., Aftab, S., & Esmaeilzadeh, F. (2010). Micronization of creatine monohydrate via Rapid Expansion of Supercritical Solution (RESS). Journal of Supercritical Fluids, 55(1), 316–324. https://doi.org/10.1016/j.supflu.2010.05.009
• Béard, E., & Braissant, O. (2010). Synthesis and transport of creatine in the CNS: Importance for cerebral functions. Journal of Neurochemistry, 115(2), 297–313. https://doi.org/10.1111/j.1471-4159.2010.06935.x
• Nasrallah, F., Feki, M., & Kaabachi, N. (2010). Creatine and Creatine Deficiency Syndromes: Biochemical and Clinical Aspects. Pediatric Neurology, 42(3), 163–171. https://doi.org/10.1016/j.pediatrneurol.2009.07.015
• Tarnopolsky, M. A. (2010). Caffeine and Creatine Use in Sport. Annals of Nutrition and Metabolism, 57(s2), 1–8. https://doi.org/10.1159/000322696
• Sahlin, K., & Harris, R. C. (2011). The creatine kinase reaction: a simple reaction with functional complexity. Amino Acids, 40(5), 1363–1367. https://doi.org/10.1007/s00726-011-0856-8
• Beal, M. F. (2011). Neuroprotective effects of creatine. Amino Acids, 40(5), 1305–1313. https://doi.org/10.1007/s00726-011-0851-0
• Turner, C. E., & Gant, N. (2014). The Biochemistry of Creatine. In Magnetic Resonance Spectroscopy (pp. 91–103). Elsevier. https://doi.org/10.1016/B978-0-12-401688-0.00007-0

• Responsible use
• Noopept
• Nootropic
• Stimulant
• Modafinil
• Pramiracetam

• Creatine (Wikipedia)
• Creatine (Examine)
• Creatine (Medlineplus)