Talk:Bromazolam

Bromazolam (XLI-268) is a triazolobenzodiazepine (TBZD) first synthesized in 1976 by Hoffman-La Roche. Although initially developed as a potential medication, it was never approved for use and remained unmarketed.^[6] Bromazolam was first identified in Sweden in 2016 by the EMCDDA and has since been found in nine countries, including Australia, Austria, China, Finland, Germany, India, Sweden, the UK, and the USA.

In European markets, Bromazolam is often sold as blue Diazepam pills,^[7] while in the United States, it is more commonly sold as Alprazolam.

Bromazolam is a chemical analog of alprazolam, where the chlorine atom in alprazolam is replaced by a bromine atom.

Bromazolam is a triazolobenzodiazepine (TBZD) and was synthesized in 1976, though it was not brought to market.^[8] It acts as a non-subtype selective agonist at the benzodiazepine (BZD) site of [[GABA_A receptors]], with a binding affinity of 2.81nM at the α1 subtype, 0.69nM at α2, and 0.62nM at α5.^[9] Benzodiazepines enhance the efficiency of GABA neurotransmission, producing sedating and anxiolytic effects^[10].

The GABA_A receptor consists of five subunits out of a possible 19, leading to a wide variety of receptor subtypes with different properties and interactions with benzodiazepines. Triazolobenzodiazepines like Bromazolam may also possess antidepressant properties, potentially due to their chemical similarity to tricyclic antidepressants.^[11]

4-8 hours with after effects being reported into the next 12 hours. In some cases people have reported feeling anxiolytic effects well into the 24+ hour mark and withdrawals/rebound anxiety not starting until Day 4/5.

Bromazolam's subjective effects include sedation, relaxation, anxiety suppression, and decreased inhibition.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience Reports

There are currently 0 experience reports available in our experience index.

Additional experience reports for Bromazolam can be found here:

• Erowid Experience Vaults: Bromazolam

Research on the toxicity of Bromazolam has not been done, however there large amounts of overdoses have been reported in relation to Bromazolam. It is strongly recommended to employ harm reduction practices while using this or any substance.

Tolerance and Addiction Potential

Long-term use of Bromazolam can lead to tolerance, physical dependence, and withdrawal symptoms associated with benzodiazepines, including the potential for life-threatening withdrawal seizures. Notably, tolerance to Bromazolam builds more quickly than with other benzodiazepines, increasing the risk of dependence.

Dangerous Interactions

Like other benzodiazepines, Bromazolam should not be mixed with alcohol or other central nervous system depressants due to the high risk of fatal overdose caused by respiratory depression.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Depressants (1,4-Butanediol, 2M2B, alcohol, benzodiazepines, barbiturates, GHB/GBL, methaqualone, opioids) - This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration. There is also an increased risk of suffocating on one's vomit while unconscious. If nausea or vomiting occurs before a loss of consciousness, users should attempt to fall asleep in the recovery position or have a friend move them into it.
• Dissociatives - This combination can unpredictably potentiate the amnesia, sedation, motor control loss and delusions that can be caused by each other. It may also result in a sudden loss of consciousness accompanied by a dangerous degree of respiratory depression. If nausea or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the recovery position or have a friend move them into it.
• Stimulants - Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states. This combination can also potentially result in severe dehydration if one's fluid intake is not closely monitored. If choosing to combine these substances, one should strictly limit themselves to a pre-set schedule of dosing only a certain amount per hour until a maximum threshold has been reached.

Bromazolam is currently unscheduled in many countries, though some states and nations have specific controls:

- **United Kingdom:** Classified as a Class C controlled substance.^[13] - **United States:** Federally unscheduled, though state-level regulations like in Virginia have placed Bromazolam into Schedule I.^[14]. - **Canada:** Classified as a Schedule IV controlled substance. - **Germany:** Subject to national control legislation.

• Responsible use

• Bromazolam (Wikipedia)
• Bromazolam (Erowid Vault)
• Bromazolam (Isomer Design)
• WHO Critical Report October 2023

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