Theacrine - PsychonautWiki


Summary sheet: Theacrine
Chemical Nomenclature
Common names Theacrine, Temurin, Temorine
Substitutive name 1,3,7,9-Tetramethyluric acid
Systematic name 1,3,7,9-Tetramethylpurine-2,6,8-trione
Class Membership
Psychoactive class Stimulant
Chemical class Xanthine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 25 mg
Light 50 - 100 mg
Common 100 - 150 mg
Strong 150 - 300 mg
Heavy 300 mg +
Total 6 - 10 hours
Onset 30 - 60 minutes

Threshold 25 mg
Common 25 - 100 mg
Total 1 - 3 hours
Onset 5 - 30 minutes

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Theacrine (also known as Teacrine) is a nootropic stimulant and a structural analog of caffeine, appearing to be synthesized from caffeine in some plants. It is a bitter, white crystalline purine alkaloid that increases activity in the brain and induces temporary improvements including enhanced alertness, wakefulness, and stimulation.[citation needed] Relative to caffeine, it displays about 2/3rds the potency in terms of the stimulation it produces.[citation needed]

The mechanisms of theacrine largely parallel those of caffeine in that while it seems to have a stimulatory effect in rodents, this only occurs at a higher dose (and the exact oral dose where it peaks with theacrine is not known).[1] Similar to caffeine, it produces a sedative effect at relatively low doses, but where this sedative effect with caffeine is at an impractically low dose with theacrine it is the dose normally consumed by tea; this may underlie why Kucha tea tends to be recommended for relaxation more than stimulation.


Theacrine's chemical structure is structurally similar to that of caffeine. It is a synthetic alkaloid with a substituted xanthine core. Xanthine is a substituted purine, which contains two fused rings, a pyrimidine and imidazole. Pryimidine is a 6 membered ring with nitrogen constituents at R1 and R3; imidazole is a 5 membered ring with nitrogen substituents at R1 and R3. Xanthine contains oxygen groups double-bonded to R2 and R6. Like caffeine, it contains additional methyl substitutions at R1, R3, and R7 of its structure, bound to the open nitrogen groups of the xanthine skeleton. It is an achiral aromatic compound.

Theacrine's chemical name is 1,3,7,9-tetramethyluric acid; in comparison, the chemical name of caffeine is 1,3,7-trimethylxanthine, with the only difference in structure being an additional methyl group on the 9-carbon and an additional ketone group, which changes caffeine's xanthine into a uric acid moiety.[2]


Theacrine acts through several mechanisms; however, like caffeine, its most important effect is to counteract a substance called adenosine that naturally circulates at high levels throughout the body (especially in the nervous system). In the brain, adenosine plays a generally protective role, part of which is to reduce neural activity levels. The theacrine molecule is structurally similar to both caffeine and adenosine, and is thus capable of binding to adenosine receptors on the surface of cells without activating them, thereby acting as a competitive inhibitor.[3]

Alongside of this, theacrine is believed to have similar effects on most of the other major neurotransmitters, including dopamine, acetylcholine, serotonin, and, in high doses, norepinephrine,[4] and to a small extent epinephrine, glutamate, and cortisol.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

Cognitive effects

Toxicity and harm potential

Theacrine is not known to cause brain damage, and has an extremely low toxicity relative to dose. There are relatively few physical side effects associated with theacrine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences of any sort.[citation needed]

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with caffeine, theacrine produces dependence with chronic use and has a low abuse potential. When dependence has developed, cravings and withdrawal effects will occur if one suddenly stops its use.

Tolerance to many of the effects of theacrine develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). It should be noted, however, that tolerance buildup does not occur as rapidly as with that of caffeine.[1] Theacrine presents cross-tolerance with antagonists adenosine receptors, meaning that after the consumption of theacrine certain stimulants such as caffeine and theobromine will have a reduced effect.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • United Kingdom: It may be illegal to produce, supply, or import this substance under the Psychoactive Substance Act 2016, which blanketly applies the aforementioned restrictions on all "psychoactive substances" with exemptions for alcohol, nicotine and "medicinal products."[7]

See also

External links


  1. 1.0 1.1 Feduccia, A. A., Wang, Y., Simms, J. A., Yi, H. Y., Li, R., Bjeldanes, L., Ye, C., Bartlett, S. E. (August 2012). "Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors". Pharmacology, Biochemistry, and Behavior. 102 (2): 241–248. doi:10.1016/j.pbb.2012.04.014. ISSN 1873-5177. 
  2. Frank, K., Patel, K., Lopez, G., Willis, B. (14 June 2018). "Theacrine Research Analysis". 
  3. Fisone, G., Borgkvist, A., Usiello, A. (1 April 2004). "Caffeine as a psychomotor stimulant: mechanism of action". Cellular and Molecular Life Sciences CMLS. 61 (7): 857–872. doi:10.1007/s00018-003-3269-3. ISSN 1420-9071. 
  4. Caffeine & Neurotransmitters – WORLD OF CAFFINE 
  5. Wang, Y., Yang, X., Zheng, X., Li, J., Ye, C., Song, X. (September 2010). "Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities". Fitoterapia. 81 (6): 627–631. doi:10.1016/j.fitote.2010.03.008. ISSN 1873-6971. 
  6. Kuhman, D. J., Joyner, K. J., Bloomer, R. J. (19 November 2015). "Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women". Nutrients. 7 (11): 9618–9632. doi:10.3390/nu7115484. ISSN 2072-6643. 
  7. Psychoactive Substances Act 2016