Talk:3-CMC

3-CMC
Chemical Nomenclature
Common names	3-CMC, Clophedrone, Crystal
Substitutive name	3-Chloromethcathinone
Systematic name	1-(3-Chlorophenyl)-2-(methylamino)-1-propanone
Class Membership
Psychoactive class	Stimulant / Entactogen
Chemical class	Cathinone
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 30 mg Light 30 - 60 mg Common 60 - 100 mg Strong 100 - 180 mg Heavy 180 - 250 mg + Duration Total 1 - 5 hours Onset 10 - 30 minutes Come up 5 - 15 minutes Peak 20 - 120 minutes Offset 1 - 3 hours After effects 2 - 6 hours ⇣ Insufflated Dosage Threshold 20 mg Light 20 - 50 mg Common 50 - 85 mg Strong 85 - 130 mg Heavy 130-200 mg + Duration Total 1 - 2 hours Onset 5 - 8 minutes Come up 1 - 5 minutes Peak 20 - 90 monites Offset 1 - 2 hours After effects 1 - 1.5 hours ⇣ Rectal Dosage Bioavailability ~ +90% Threshold 30 mg Light 30 - 40 mg Common 40 - 80 mg Strong 80 - 120 mg Heavy 120-180 mg + Duration Total 1 - 2 hours Onset 1 - 15 minutes Come up 5 - 10 minutes Peak 20 - 60 minutes Offset 30 - 90 minutes After effects 60 - 90 minutes DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

3-Chloromethcathinone (also known as 3-CMC or clophedrone ^[2]) is a novel stimulant-entactogen substance of the cathinone class. It is the analogue of 3-Chloromethamphetamine (3-CMA) and structurally closely related to the antidepressant and anti-addictive medication bupropion. The complete working has not been fully studied, however it is known to promote the release of dopamine, noradrenaline and serotonin just like other Methcathinone substances.^{[3] [4]}

3-CMC has been sold online on the research chemical market as a designer drug since 2013 in mainly European countries^[5]. 3-CMC has been marketed as the legal successor of 3-MMC in the Netherlands since its ban in October 2021 ^[6].

The subjective effects are reported to be similar, but weaker, to those of 3-MMC. This mostly includes stimulation, anxiety suppression, disinhibition, enhanced empathy and sociability, relaxation, increased libido, and euphoria. It is also reported to be subject to compulsive redosing which can lead to psychosis and habitual use.

The related 4-CMC is a known neurotoxin, and research shows that 3-CMC is neurotoxic in mice^[7]. If 3-CMC's mechanism of action is inherently neurotoxic then damage to human health may be incurred even at moderate recreational doses. Anecdotal reports mention highly concerning cardiovascular and neurological symptoms after frequent or high-dose use, which seems to confirm this suspicion. As such, it is strongly advised to avoid this substance completely. Use excessive harm reduction practices if planning on using this substance, and avoid redosing.