MCPP

mCPP is a drug in the phenylpiperazine class. On the meta-position of the phenyl group, there is a chlorine atom.

mCPP possesses significant affinity for the 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_2A, 5-HT_2B, 5-HT_2C, 5-HT₃, and 5-HT₇, as well as the SERT (serotonin transporter).^[5] It also has some affinity for α₁-adrenergic, α₂-adrenergic, H₁, I₁ (Imidazoline receptor), and NET (norepinephrine transporter).^[5][6] It behaves as an agonist at most serotonin receptors.^[7][8] mCPP has been shown to act not only as a serotonin reuptake inhibitor but as a serotonin releasing agent as well.^[9]

mCPP's strongest actions are at the 5-HT_2B and 5-HT_2C receptors and its discriminative cue is mediated primarily by 5-HT_2C.^[5][10][11] Its negative effects such as anxiety, headaches, and appetite loss are likely mediated by its actions on the 5-HT_2C receptor.^[12][13][14] Other effects of mCPP include nausea, hypoactivity, and penile erection, the latter two the result of increased 5-HT_2C activity and the former likely via 5-HT₃ stimulation.^[15][16][17]

mCPP acts as a partial agonist of the human 5-HT_2C receptor but as an antagonist of the human 5-HT_2A and 5-HT_2B receptors.^[18][19] In accordance with its lack of agonism towards the human 5-HT_2A receptor, there are no reports that mCPP produces hallucinogenic effects in humans.^[18]

mCPP is an active metabolite of the antidepressant trazodone.^[20]

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: mCPP

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

mCPP is not known to be addictive, but there are not any studies exclusively on its addiction potential.

Dangerous interactions

mCPP is metabolized by cytochrome P450 2D6^[21], and concurrently taking inhibitors of that enzyme results in increased serum levels of mCPP. Commonly encounter inhibitors of CYP2D6 include ciprofloxacin, bupropion (Wellbutrin), fluoxetine (Prozac) and grapefruit juice.^[22]

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• 25x-NBOMe & 25x-NBOH - 25x compounds are highly stimulating and physically straining. Combinations with MCPP should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
• Alcohol - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• DXM - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
• MDMA - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
• MXE - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
• Dissociatives - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
• Stimulants - MCPP may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
• Tramadol - Tramadol is known to lower the seizure threshold^[23] and combinations with stimulants may further increase this risk.

• MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, and some antidepressants.^[24]
• Cocaine - This combination may increase strain on the heart.

Serotonin syndrome risk

Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.

• MAOIs - Such as banisteriopsis caapi, syrian rue, phenelzine, selegiline, and moclobemide.^[25]
• Serotonin releasers - Such as MDMA, 4-FA, methamphetamine, methylone and αMT.
• SSRIs - Such as citalopram and sertraline
• SNRIs - Such as tramadol and venlafaxine
• 5-HTP

• Austria: Since January 1, 2012, mCPP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).^{[citation needed]}
• Belgium: mCPP is a controlled substance as of October 22, 2006.^[26]
• Brazil: mCPP is a controlled substance (lista F2 da Portaria SVS/MS 344/98) since November 2008.^[27]
• China: As of October 2015, mCPP is a controlled substance in China.^[28]
• Denmark: mCPP is a controlled substance as of December 3, 2005.^[29]
• Finland: mCPP is a controlled substance.^{[citation needed]}
• Germany: mCPP is controlled under Anlage II BtMG (Narcotics Act, Schedule II)^[30] as of March 1, 2007.^[31] It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.^[32]
• Greece: mCPP is a controlled substance as of January 20, 2005.^[29]
• Hungary: mCPP is a controlled substance as of January 1, 2006.^[29]
• Japan: mCPP is a controlled substance since 2006.^{[citation needed]}
• Lithuania: mCPP is a controlled substance as of July 1, 2006.^[29]
• Norway: mCPP is a controlled substance.^{[citation needed]}
• Poland: mCPP is a controlled substance.^{[citation needed]}
• Russia: mCPP is a controlled substance.^{[citation needed]}
• Sweden: mCPP is a controlled substance.^{[citation needed]}
• Switzerland: mCPP is a controlled substance specifically named under Verzeichnis D.^[33]
• United Kingdom: mCPP is a Class C, Schedule 4 (Part 1) drug in the United Kingdom.^[34]
• United States: mCPP is unscheduled in the United States, but could be considered an analogue of benzylpiperazine if it is sold for human consumption.^{[citation needed]}

• Responsible use
• Stimulant
• Entactogen
• Benzylpiperazine

• mCPP (Wikipedia)
• mCPP (Erowid Vault)
• mCPP (Isomer Design)