Restless legs (also known as restless legs syndrome or RLS) is a neurological disorder characterized by an irresistible urge to move one's body to stop uncomfortable or odd sensations. It most commonly affects the legs but can also affect the arms, torso, and head. During this state, moving the affected body part reduces the uncomfortable sensations, providing temporary relief.
RLS sensations can range from pain, an aching in the muscles, "an itch you can't scratch", an unpleasant "tickle that won't stop", or even a crawling feeling. The sensations typically begin or intensify during quiet wakefulness, such as when relaxing, reading, studying, or trying to sleep.
Restless legs syndrome is most commonly induced during the withdrawal symptoms of many depressants, such as opioids or benzodiazepines, and during the offset of many stimulants, such as methamphetamine, cocaine, and MDMA. However, it can also occur under the influence of deliriants such as DPH and datura.
Compounds within our psychoactive substance index which may cause this effect include:
Anecdotal reports which describe this effect within our experience index include: