4-AcO-DiPT - PsychonautWiki


Summary sheet: 4-AcO-DiPT
Chemical Nomenclature
Common names 4-AcO-DiPT, 4-Acetoxy-DiPT, Ipracetin, Aces
Substitutive name 4-Acetoxy-N,N-diisopropyltryptamine
Systematic name 3-[2-(Diisopropylamino)ethyl]-1H-indol-4-yl acetate
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 3 mg
Light 5 - 15 mg
Common 15 - 30 mg
Strong 30 - 45 mg
Heavy 45 mg +
Total 3 - 4 hours
Onset 15 - 40 minutes
Come up 20 - 40 minutes
Peak 1.5 - 2 hours
Offset 1 - 1.5 hours
After effects 2 - 6 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


4-Acetoxy-N,N-diisopropyltryptamine (also known as 4-AcO-DiPT, 4-Acetoxy-DiPT, Ipracetin, Iprocetyl and colloquially as "4-Ace"[1] or "Aces"[1]) is a lesser-known synthetic psychedelic substance of the tryptamine chemical class that produces a unique mixture of physically euphoric, stimulating, and atypically minimal visual and introspective psychedelic effects when administered.

It has been described in early online reports as being only vaguely similar to structurally-related tryptamine substances such as psilocin or 4-AcO-DMT but with the disinhibiting, physically euphoric and libidinous signature of psychedelics like 5-MeO-DiPT, and an atypically short duration of around 3 - 4 hours. It has since been reported to be slightly longer lasting and mildly less potent than 4-HO-DiPT (also known as Iprocin) with an active dose reported as between 15 and 40 mg.[2]

4-AcO-DiPT is primarily thought to act as a prodrug to 4-HO-DiPT, a substance which Alexander Shulgin comments on in his book TiHKAL. In it he writes that he "truly doubt(s) that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitive to dose, at least one that is active orally."[3] Anecdotal reports dating from at least 1999 reveals that these properties are largely preserved with 4-AcO-DiPT, with the exception of a less rapid and potentially jarring onset, slightly extended duration and decreased physical side-effects from the excessive stimulation and restlessness that 4-HO-DiPT is commonly reported to produce, making it a more comfortable experience overall.[2]

Today, 4-AcO-DiPT is rarely able to be acquired on the consumer market and when it is, is almost exclusively distributed as a gray-area research chemical online for recreational and proclaimed entheogenic purposes. It is an example of the early wave of psychedelic research chemical that were explored following the wake of its initial synthesis and documentation in TiHKAL, before the emergence of an easily-accessible network of online research chemical vendors during the early 2000s.[citation needed]

Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-AcO-DiPT. Users are advised to proceed with caution when choosing to use this substance.


4-Acetoxy-N,N-diisopropyltryptamine, or 4-AcO-DiPT, is a synthetic indole alkaloid molecule of the tryptamine chemical class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-DiPT is substituted at R4 of its indole heterocycle with an acetoxy (-AcO) functional group CH3COO−. It also contains two diisopropyl chains bound to the terminal amine RN of its base tryptamine backbone (i.e. DiPT).

Structurally, 4-AcO-DiPT is the the acetate ester analog of DiPT, N-substituted isopropyl homolog of 4-HO-DMT (Psilocin), and the N-substituted diisopropyl analog of 4-AcO-DMT.[4]


Further information: Serotonergic psychedelic


4-AcO-DiPT likely acts as a 5-HT2A partial agonist. The primary psychedelic effects are believed to come from 4-AcO-DiPT's efficacy at the 5-HT2A receptors, although a number of other receptors may be involved as well. However, the role of these interactions and how they result in the psychedelic experience remains subject to ongoing scientific investigation.


4-AcO-DiPT is reported to produce effects that are almost identical to its de-acetylated counterpart (4-HO-DiPT), albeit with a slightly extended duration and slower ramp-up in its activity.[2] This is in a similar manner that substances like 4-AcO-DMT/4-HO-DMT, 4-AcO-MET/4-HO-MET, and 4-AcO-DET/4-HO-DET all seem to share the core pharmacokinetic relationship to their counterparts, suggesting that the 4-acetoxy tryptamine compounds are largely deacetylated into their respective 4-hydroxy homologs before exerting their main effects, though the degree and manner to which this occurs has yet to be scientifically validated..

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Visual effects

Cognitive effects

Auditory effects

After effects

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:


  • Cannabis - When used in conjunction with cannabis, both the visual and cognitive effects of 4-AcO-DiPT can be intensified and extended with extreme efficacy. This should be done with extreme caution, however, especially if one is not experienced with psychedelics. Many users typically report a dramatically intensified visual and "body high"; however, this can also amplify the anxiety, confusion and psychosis producing aspects of cannabis significantly, so extreme caution is advised when combining these two substances.
  • Alcohol - This interaction is not typically recommended due to alcohol’s diuretic and physically taxing effect which can negatively affect a trip if taken in high dosages. This combination is, however, considered to be reasonably safe in low doses and when used in moderate quantities, can often "take the edge off" a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit in a more physically draining way.
  • Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of a psilocin trip. They are very efficient at stopping bad trips at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose, however, due to the very high habit-forming and addiction potential that benzodiazepines possess.

Toxicity and harm potential

The toxicity and long-term health effects of recreational 4-AcO-DiPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-AcO-DiPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-AcO-DiPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (although nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-AcO-DiPT is not known to be habit-forming and the desire to use it can actually decrease with repeated administration. As with most psychedelics, it is generally considered to have a built-in, self-regulating aspect. However, it should be noted that due to the distinctly hedonic effects this substance produces, it may possess a higher liability for frequent or excessive consumption relative to most psychedelics.

Tolerance to the effects of 4-AcO-DiPT is built almost immediately after ingestion. Afterward, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-AcO-DiPT presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-AcO-DiPT all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Denmark: 4-AcO-DiPT is a Schedule B controlled substance in Denmark.[6]
  • Germany: 4-AcO-DiPT is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019.[7][8] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[9]
  • Japan: 4-AcO-DiPT is a controlled substance in Japan.[10]
  • Sweden: 4-AcO-DiPT is illegal to sell or possess in Sweden.[11]
  • Switzerland: 4-AcO-DiPT is a controlled substance specifically named under Verzeichnis E.[12]
  • United Kingdom: 4-AcO-DiPT is a Class A drug in the UK as it is an ester of the drug 4-HO-DiPT[13], which is a Class A drug as a result of the tryptamine catch-all clause.[14]
  • United States: 4-AcO-DiPT is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT) which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.[citation needed]

See also

External links


  1. 1.0 1.1 Erowid 4-Acetoxy-DiPT Vault, Erowid 
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Erowid 4-Acetoxy-DiPT Vaults : Primer, Erowid, 1999 
  3. Shulgin, A., Shulgin, A. (1991), Erowid Online Books : “TIHKAL” - #17 4-HO-DIPT 
  4. 4-Acetoxy-N,N-diisopropyltryptamine, National Center for Biotechnology Information. PubChem Compound Database, retrieved 2 May 2017 
  5. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. ISSN 1556-9039. 
  6. Sundheds- og Ældreministeriet, Bekendtgørelse om euforiserende stoffer 
  7. "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019. 
  8. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019. 
  9. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019. 
  10. ホーム > 政策について > 分野別の政策一覧 > 健康・医療 > 医薬品・医療機器 > 薬物乱用防止に関する情報 (in Japanese) 
  11. Svensk författningssamling (PDF) (in Swedish) 
  12. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  13. Misuse of Drugs Act 1971 
  14. Misuse of Drugs Act 1971