Talk:ΒOH-2C-B

Experience reports of βOH-2C-B began to appear on the internet circa 2020, following its appearance online by gray-market research chemical vendors.

βOH-2C-B is considered a relatively obscure substance, even among research chemicals. An analysis of the Google search history between 2004-2024 shows that βOH-2C-B was inconsistently searched for during this time (about 32 times less often than 2C-B).^[1]

βOH-2C-B, or beta-hydroxy 2C-B, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH₂) group through an ethyl chain. βOH-2C-B contains the structure of 2C-B substituted with a hydroxy group at the beta carbon of the structure (R₁). βOH-2C-B contains methoxy functional groups CH₃O- attached to carbons R₂ and R₅ as well as a bromine atom attached to carbon R₄ of the phenyl ring. βOH-2C-B belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.^[2]

βOH-2C-B likely acts as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from its efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience reports

There are no reports describing the effects of this compound within our experience index, but some experience reports can be found here:

• Erowid Experience Vaults: BOH-2C-B

The toxicity and long-term health effects of recreational βOH-2C-B use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because βOH-2C-B is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried βOH-2C-B suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Some users have reported headaches and migraines towards the end of their βOH-2C-B experience, which may indicate a potential toxicity.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

As with psychedelics in general, βOH-2C-B is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of βOH-2C-B are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). βOH-2C-B presents cross-tolerance with all psychedelics, meaning that after the consumption of βOH-2C-B, all psychedelics will have a reduced effect.

• Germany: βOH-2C-B is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.^[3][4] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.^[5]
• Netherlands: βOH-2C-B is a 2-phenethylamine ring-substituted derivative and thus falls under the 2024 analogue update to the Dutch Opium Act.
• United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.^[6]
• United States: βOH-2C-B is unscheduled in the U.S., but may be considered an analogue of 2C-B under the Federal Analogue Act and thus a Schedule I drug.{{https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/april/atta-nya-amnen-klassas-som-narkotika/}}

• Responsible use
• 2C-B
• 2C-x
• Bk-MDMA
• Phenethylamine
• Hallucinogen
• Psychedelics

• βOH-2C-B (Wikipedia)
• βOH-2C-B (Isomer Design)
• Bk-2CB (Bluelight)